Evidence map›Paper›PMID 25120531›Full record

ReviewFrontiers in endocrinology2014

Estrogens and stem cells in thyroid cancer.

Mariangela Zane, Veronica Catalano, Emanuela Scavo, Marco Bonanno, Maria Rosa Pelizzo, Matilde Todaro, Giorgio Stassi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Increased risk of papillary thyroid cancer related to hormonal factors in women.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  2. Pooled it
  3. Dual COX-2/5-LOX inhibitors fromFrontiers in chemistry · 2023
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Cancer Risk in Women Treated with Fertility Drugs According to Parity Status-A Registry-based Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Article
  9. Article
  10. Estrogen and thyroid cancer is a stem affair: A preliminary study.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mariangela ZaneDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy ; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua , Padua , Italy.
Veronica CatalanoDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.
Emanuela ScavoDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.
Marco BonannoDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.
Maria Rosa PelizzoDepartment of Surgical, Oncological and Gastroenterological Sciences, University of Padua , Padua , Italy.
Matilde TodaroDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.
Giorgio StassiDepartment of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.
University of Palermo · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent discoveries highlight the emerging role of estrogens in the initiation and progression of different malignancies through their interaction with stem cell (SC) compartment. Estrogens play a relevant role especially for those tumors bearing a gender disparity in incidence and aggressiveness, as occurs for most thyroid diseases. Although several experimental lines suggest that estrogens promote thyroid cell proliferation and invasion, their precise contribution in SC compartment still remains unclear. This review underlines the interplay between hormones and thyroid function, which could help to complete the puzzle of gender discrepancy in thyroid malignancies. Defining the association between estrogen receptors' status and signaling pathways by which estrogens exert their effects on thyroid cells is a potential tool that provides important insights in pathogenetic mechanisms of thyroid tumors.

Indexed as

cancer stem cellsestrogensgrowth factorsstem cellsthyroid cancerthyroid hormones

Identifiers

PMID25120531
PMCPMC4110518
OpenAlexW2130764746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.