ReviewFrontiers in physiology2014
Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis.Rheumatology (Oxford, England) · 2023Pooled it
- Effects of Dietary Selenium Sources on Meat Quality, Tissue Selenium Deposition, and Transcriptome Profiling ofFoods (Basel, Switzerland) · 2026Article
- Article
- Special Issue "Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction".International journal of molecular sciences · 2026Article
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Fibronectin is required for proper extracellular matrix organization and cardiac outflow tract elongation inFrontiers in cell and developmental biology · 2026Article
- A 3D ColMA-Based Tenogenic Microenvironment Unveils the Behavior of Tendon Stem/Progenitor Cells (TSPCs) from Tendinopathic Surgical Explants.Bioengineering (Basel, Switzerland) · 2025Article
- Bidirectional Interaction Between PGEProteomes · 2025Article
- Inhibition of tenascin C rescues abnormally reduced Na currents in dystrophin-deficient ventricular cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2025Article
- Spiny mice (Acomys) have evolved cellular features to support regenerative healing.Annals of the New York Academy of Sciences · 2025Review
- Biomaterials in tissue repair and regeneration: key insights from extracellular matrix biology.Frontiers in medical technology · 2025Review
- Transcriptional regulation of postnatal aortic development.Cells & development · 2024Article
- Matricellular proteins in immunometabolism and tissue homeostasis.BMB reports · 2024Review
- Altered extracellular matrix-related pathways accelerate the transition from normal to prefibroid myometrium in Black women.American journal of obstetrics and gynecology · 2024Article
- Tenascin C activates the toll‑like receptor 4/NF‑κB signaling pathway to promote the development of polycystic ovary syndrome.Molecular medicine reports · 2024Article
- The diagnostic value of tenascin-C in acute aortic syndrome.Journal of geriatric cardiology : JGC · 2024Article
- How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.Science advances · 2023Article
- MiR-495-3p depletion contributes to myocardial ischemia/reperfusion injury in cardiomyocytes by targeting TNC.Regenerative therapy · 2022Article
- The role of physical cues in the development of stem cell-derived organoids.European biophysics journal : EBJ · 2022Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living tissue is composed of cells and extracellular matrix (ECM). In the heart and blood vessels, which are constantly subjected to mechanical stress, ECM molecules form well-developed fibrous frameworks to maintain tissue structure. ECM is also important for biological signaling, which influences various cellular functions in embryonic development, and physiological/pathological responses to extrinsic stimuli. Among ECM molecules, increased attention has been focused on matricellular proteins. Matricellular proteins are a growing group of non-structural ECM proteins highly up-regulated at active tissue remodeling, serving as biological mediators. Tenascin-C (TNC) is a typical matricellular protein, which is highly expressed during embryonic development, wound healing, inflammation, and cancer invasion. The expression is tightly regulated, dependent on the microenvironment, including various growth factors, cytokines, and mechanical stress. In the heart, TNC appears in a spatiotemporal-restricted manner during early stages of development, sparsely detected in normal adults, but transiently re-expressed at restricted sites associated with tissue injury and inflammation. Similarly, in the vascular system, TNC is strongly up-regulated during embryonic development and under pathological conditions with an increase in hemodynamic stress. Despite its intriguing expression pattern, cardiovascular system develops normally in TNC knockout mice. However, deletion of TNC causes acute aortic dissection (AAD) under strong mechanical and humoral stress. Accumulating reports suggest that TNC may modulate the inflammatory response and contribute to elasticity of the tissue, so that it may protect cardiovascular tissue from destructive stress responses. TNC may be a key molecule to control cellular activity during development, adaptation, or pathological tissue remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.