ArticleFrontiers in neural circuits2014
Gain control mechanisms in spinal motoneurons.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Association of Preoperative Asymmetry in Vertical Ground-Reaction Force With Knee Extensor Symmetry 1 Year After Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2026Article
- Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner.Experimental physiology · 2026Article
- Intrinsic Motoneuron Excitability Differentiates Sarcopenic, Nonsarcopenic and Athletic Ageing Phenotypes.Journal of cachexia, sarcopenia and muscle · 2025Article
- Motor unit adaptation to disuse: crossing the threshold from firing rate suppression to neuromuscular junction transmission.The Journal of physiology · 2025Review
- Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease.The European journal of neuroscience · 2025Article
- Clonidine for the management of crises in stiff-person syndrome.Journal of neurology · 2025Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Effects of neuromuscular electrical stimulation on neuromuscular function and muscle quality in patient following anterior cruciate ligament reconstruction.Journal of exercise rehabilitation · 2025Article
- Central mechanisms of muscle tone regulation: implications for pain and performance.Frontiers in neuroscience · 2024Article
- Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy.Brain : a journal of neurology · 2023Article
- Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.Journal of neurophysiology · 2023Article
- Neural dysregulation in post-COVID fatigue.Brain communications · 2023Article
- Small sensory spinal lesions that affect hand function in monkeys greatly alter primary afferent and motor neuron connections in the cord.The Journal of comparative neurology · 2022Article
- The Neuromuscular Fatigue-Induced Loss of Muscle Force Control.Sports (Basel, Switzerland) · 2022Review
- Aging and skeletal muscle force control: Current perspectives and future directions.Scandinavian journal of medicine & science in sports · 2022Review
- The control and training of single motor units in isometric tasks are constrained by a common input signal.eLife · 2022Article
- Diminished neuromuscular system adaptability following anterior cruciate ligament injury: Examination of knee muscle force variability and complexity.Clinical biomechanics (Bristol, Avon) · 2021Article
- Firing rate trajectories of human occipitofrontalis motor units in response to triangular voluntary contraction intensity.Experimental brain research · 2021Article
- The relationship of agonist muscle single motor unit firing rates and elbow extension limb movement kinematics.Experimental brain research · 2021Article
- Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.Journal of neurophysiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motoneurons provide the only conduit for motor commands to reach muscles. For many years, motoneurons were in fact considered to be little more than passive "wires". Systematic studies in the past 25 years however have clearly demonstrated that the intrinsic electrical properties of motoneurons are under strong neuromodulatory control via multiple sources. The discovery of potent neuromodulation from the brainstem and its ability to change the gain of motoneurons shows that the "passive" view of the motor output stage is no longer tenable. A mechanism for gain control at the motor output stage makes good functional sense considering our capability of generating an enormous range of forces, from very delicate (e.g., putting in a contact lens) to highly forceful (emergency reactions). Just as sensory systems need gain control to deal with a wide dynamic range of inputs, so to might motor output need gain control to deal with the wide dynamic range of the normal movement repertoire. Two problems emerge from the potential use of the brainstem monoaminergic projection to motoneurons for gain control. First, the projection is highly diffuse anatomically, so that independent control of the gains of different motor pools is not feasible. In fact, the system is so diffuse that gain for all the motor pools in a limb likely increases in concert. Second, if there is a system that increases gain, probably a system to reduce gain is also needed. In this review, we summarize recent studies that show local inhibitory circuits within the spinal cord, especially reciprocal and recurrent inhibition, have the potential to solve both of these problems as well as constitute another source of gain modulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.