ArticleNature communications2014
Documentation and localization of force-mediated filamin A domain perturbations in moving cells.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disorders.Brain : a journal of neurology · 2025Review
- Intermediate filaments and their associated molecules.Journal of biomedical research · 2025Article
- Interaction of LARP4 to filamin A mechanosensing domain regulates cell migrations.Frontiers in cell and developmental biology · 2023Article
- Degradation of ribosomal and chaperone proteins is attenuated during the differentiation of replicatively aged C2C12 myoblasts.Journal of cachexia, sarcopenia and muscle · 2022Article
- A protective role for <i>Drosophila</i> Filamin in nephrocytes via Yorkie mediated hypertrophy.Life science alliance · 2022Article
- Role of chaperone-assisted selective autophagy (CASA) in mechanical stress protection of periodontal ligament cells.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2022Article
- Maintaining proteostasis under mechanical stress.EMBO reports · 2021Review
- Probing mechanobiological role of filamin A in migration and invasion of human U87 glioblastoma cells using submicron soft pillars.Nano convergence · 2021Article
- Spatiotemporal patterning of photoresponsive DNA-based hydrogels to tune local cell responses.Nature communications · 2021Article
- Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.Nature · 2020Article
- Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.Journal of the American Society of Nephrology : JASN · 2020Article
- Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration.Frontiers in cell and developmental biology · 2020Review
- The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Filamin A mediates isotropic distribution of applied force across the actin network.The Journal of cell biology · 2019Article
- Septo-optic dysplasia caused by a novel FLNA splice site mutation: a case report.BMC medical genetics · 2019Article
- The Host Scaffolding Protein Filamin A and the Exocyst Complex Control Exocytosis during InlB-Mediated Entry ofInfection and immunity · 2019Article
- PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.Biology open · 2015Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Endogenously and externally generated mechanical forces influence diverse cellular activities, a phenomenon defined as mechanotransduction. Deformation of protein domains by application of stress, previously documented to alter macromolecular interactions in vitro, could mediate these effects. We engineered a photon-emitting system responsive to unfolding of two repeat domains of the actin filament (F-actin) crosslinker protein filamin A (FLNA) that binds multiple partners involved in cell signalling reactions and validated the system using F-actin networks subjected to myosin-based contraction. Expressed in cultured cells, the sensor-containing FLNA construct reproducibly reported FLNA domain unfolding strikingly localized to dynamic, actively protruding, leading cell edges. The unfolding signal depends upon coherence of F-actin-FLNA networks and is enhanced by stimulating cell contractility. The results establish protein domain distortion as a bona fide mechanism for mechanotransduction in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.