ArticleIndian journal of pediatrics2015
Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year.
Article in Indian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma.Bioscience reports · 2017Trial
- Association of exposure to synthetic phenols and metal(loid)s with early puberty in Spanish girls: a multicentric case-control study.European journal of pediatrics · 2026Article
- Evaluating Phthalates and Bisphenol in Foods: Risks for Precocious Puberty and Early-Onset Obesity.Nutrients · 2024Review
- Premature Thelarche: An Updated Review.Current pediatric reviews · 2024Review
- Article
- Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls.Annals of pediatric endocrinology & metabolism · 2019Article
- The effects of perinatal bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the prefrontal cortex and hippocampus of rats.Brain and behavior · 2019Article
- Association of Prenatal Urinary Concentrations of Phthalates and Bisphenol A and Pubertal Timing in Boys and Girls.Environmental health perspectives · 2018Article
- The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature.International journal of environmental research and public health · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.
methodsA total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.
resultsSerum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06-51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.
conclusionsThis hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.
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Registered trials
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