ArticleJournal of molecular histology2014
Expression of cytokeratin 8, vimentin, syndecan-1 and Ki-67 during human tooth development.
Article in Journal of molecular histology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Spatio-Temporal Regulation of IGFs in Enamel Development: Molecular Mechanisms From Ameloblast Polarity to Mineralization Homeostasis.Stem cells international · 2025Review
- The significant role of glycosaminoglycans in tooth development.Glycobiology · 2024Review
- Article
- Cell Differentiation and Replication during Postnatal Development of the Murine First Molar.Biology · 2021Article
- Novel approach for quantification of multiple immunofluorescent signals using histograms and 2D plot profiling of whole-section panoramic images.Scientific reports · 2021Article
- Spatio-Temporal Expression Pattern of Ki-67, pRB, MMP-9 and Bax in Human Secondary Palate Development.Life (Basel, Switzerland) · 2021Article
- Primordial odontogenic tumor: a case report and literature review.Diagnostic pathology · 2019Review
- Expression of Vimentin in hair follicle growth cycle of inner Mongolian Cashmere goats.BMC genomics · 2018Article
- Syndecans and Enzymes Involved in Heparan Sulfate Biosynthesis and Degradation Are Differentially Expressed During Human Odontogenesis.Frontiers in physiology · 2018Article
- Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth.Frontiers in physiology · 2017Article
- Decellularized Swine Dental Pulp as a Bioscaffold for Pulp Regeneration.BioMed research international · 2017Article
- Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study.Organogenesis · 2016Article
- FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2.Journal of molecular histology · 2016Article
- Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars.Journal of molecular histology · 2015Article
- Distribution of syndecan-1 protein in developing mouse teeth.Frontiers in physiology · 2014Article
- Membrana preformativa: Unveiling the unexplored facets of dental development.Journal of oral biology and craniofacial researchArticle
- Primordial odontogenic tumour: Report of a novel entity - The third case from India.Journal of oral and maxillofacial pathology : JOMFPArticle
- A comparative study of syndecan-1 expression in different odontogenic tumors.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal parts, but few cells, sparsely distributed throughout the tooth germ, strongly expressed CK8. As development progressed, CK8 expression increased to strong in preameloblasts, while expression of vimentin increased to moderate in the epithelial and mesenchymal tooth parts, particularly in the dental papilla and sac. Co-expression of CK8 and vimentin was observed in some parts of the tooth germ, and was increasing in the differentiating preameloblasts and preodontoblasts. Syndecan-1 showed characteristic shift of expression from epithelial to mesenchymal tooth parts, being particularly strong in dental papilla, sac and cervical loops, while co-expression of Ki-67/syndecan-1 was strong in the dental papilla. Our study demonstrated spatio-temporal expression and restricted co-expression of the investigated markers, indicating participation of CK8 and vimentin in cell proliferation and migration, and differentiation of preodontoblasts and preameloblasts. Our data also suggest involvement of syndecan-1 in morphogenesis of the developing tooth crown and cervical loops, and together with CK8 and vimentin in differentiation of preameloblasts and preodontoblasts.
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