ArticleEuropean journal of nuclear medicine and molecular imaging2015
Non-small-cell lung cancer resectability: diagnostic value of PET/MR.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic potential of [Japanese journal of radiology · 2024Pooled it
- Diagnostic performance of whole-body [European radiology · 2024Pooled it
- [Frontiers in medicine · 2024Pooled it
- Prospective comparison ofEuropean journal of nuclear medicine and molecular imaging · 2019Trial
- Prediction of lymph node metastasis in non-small cell lung cancer and its correlation with Ki-67 expression: a comparative study between intravoxel incoherent motion imaging andBMC medical imaging · 2026Article
- Application of diffusion kurtosis imaging andFrontiers in oncology · 2022Article
- Fabrication and evaluation of bilateral Helmholtz radiofrequency coil for thermo-stable breast image with reduced artifacts.Journal of applied clinical medical physics · 2022Article
- An international expert opinion statement on the utility of PET/MR for imaging of skeletal metastases.European journal of nuclear medicine and molecular imaging · 2021Article
- Hybrid PET/MRI in non-small cell lung cancer (NSCLC) and lung nodules-a literature review.European journal of nuclear medicine and molecular imaging · 2021Review
- PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques.Medical physics · 2020Review
- Prognostic impact of combining whole-body PET/CT and brain PET/MR in patients with lung adenocarcinoma and brain metastases.European journal of nuclear medicine and molecular imaging · 2019Article
- Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.The British journal of radiology · 2018Review
- FDG Whole-Body PET/MRI in Oncology: a Systematic Review.Nuclear medicine and molecular imaging · 2017Review
- Thoracic staging withEuropean radiology · 2017Article
- SUV-quantification of physiological lung tissue in an integrated PET/MR-system: Impact of lung density and bone tissue.PloS one · 2017Article
- Preoperative staging of non-small cell lung cancer: prospective comparison of PET/MR and PET/CT.European radiology · 2016Article
- Standardized Uptake Values from PET/MRI in Metastatic Breast Cancer: An Organ-based Comparison With PET/CT.The breast journal · 2016Article
- 18F-FDG PET/CT and PET/MRI Perform Equally Well in Cancer: Evidence from Studies on More Than 2,300 Patients.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Review
- PET/MRI in Oncological Imaging: State of the Art.Diagnostics (Basel, Switzerland) · 2015Review
- Thoracic staging of non-small-cell lung cancer using integrated (18)F-FDG PET/MR imaging: diagnostic value of different MR sequences.European journal of nuclear medicine and molecular imaging · 2015Article
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Authors and funding
13 authors.
Funding
Abstract
purposeTo assess the diagnostic performance of PET/MR in patients with non-small-cell lung cancer.
methodsFifty consecutive consenting patients who underwent routine (18)F-FDG PET/CT for potentially radically treatable lung cancer following a staging CT scan were recruited for PET/MR imaging on the same day. Two experienced readers, unaware of the results with the other modalities, interpreted the PET/MR images independently. Discordances were resolved in consensus. PET/MR TNM staging was compared to surgical staging from thoracotomy as the reference standard in 33 patients. In the remaining 17 nonsurgical patients, TNM was determined based on histology from biopsy, imaging results (CT and PET/CT) and follow-up. ROC curve analysis was used to assess accuracy, sensitivity and specificity of the PET/MR in assessing the surgical resectability of primary tumour. The kappa statistic was used to assess interobserver agreement in the PET/MR TNM staging. Two different readers, without knowledge of the PET/MR findings, subsequently separately reviewed the PET/CT images for TNM staging. The generalized kappa statistic was used to determine intermodality agreement between PET/CT and PET/MR for TNM staging.
resultsROC curve analysis showed that PET/MR had a specificity of 92.3 % and a sensitivity of 97.3 % in the determination of resectability with an AUC of 0.95. Interobserver agreement in PET/MR reading ranged from substantial to perfect between the two readers (Cohen's kappa 0.646 - 1) for T stage, N stage and M stage. Intermodality agreement between PET/CT and PET/MR ranged from substantial to almost perfect for T stage, N stage and M stage (Cohen's kappa 0.627 - 0.823).
conclusionIn lung cancer patients PET/MR appears to be a robust technique for preoperative staging.
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