Trial reportNPJ primary care respiratory medicine2014
Diagnostic accuracy of pre-bronchodilator FEV1/FEV6 from microspirometry to detect airflow obstruction in primary care: a randomised cross-sectional study.
Trial report in NPJ primary care respiratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Accuracy of portable spirometers in the diagnosis of chronic obstructive pulmonary disease A meta-analysis.NPJ primary care respiratory medicine · 2022Pooled it
- The Effectiveness and Harms of Screening for Chronic Obstructive Pulmonary Disease: An Updated Systematic Review and Meta-Analysis.Journal of Korean medical science · 2022Pooled it
- Performance of alternative COPD case-finding tools: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Diagnostic accuracy of screening tests for COPD: a systematic review and meta-analysis.BMJ open · 2015Pooled it
- Diagnostic performance of FEVChronic respiratory diseasePooled it
- Point of care microspirometry to facilitate the COPD diagnostic process in primary care: a clustered randomised trial.NPJ primary care respiratory medicine · 2018Trial
- FEV1/FEV6 Cutoff Points to Avoid False Negatives When Using Portable Devices, PICO-6Journal of clinical medicine · 2025Article
- Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding.American journal of respiratory and critical care medicine · 2024Article
- Current Progress of COPD Early Detection: Key Points and Novel Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Article
- Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease.The Korean journal of internal medicine · 2021Article
- Novel App-Based Portable Spirometer for the Early Detection of COPD.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Accuracy of Vitalograph lung monitor as a screening test for COPD in primary care.NPJ primary care respiratory medicine · 2020Article
- Peak flow meter with a questionnaire and mini-spirometer to help detect asthma and COPD in real-life clinical practice: a cross-sectional study.NPJ primary care respiratory medicine · 2017Article
- Development and validation of the Salzburg COPD-screening questionnaire (SCSQ): a questionnaire development and validation study.NPJ primary care respiratory medicine · 2017Article
- Community pharmacy-based case finding for COPD in urban and rural settings is feasible and effective.International journal of chronic obstructive pulmonary disease · 2017Article
- Multicenter study of the COPD-6 screening device: feasible for early detection of chronic obstructive pulmonary disease in primary care?International journal of chronic obstructive pulmonary disease · 2017Article
- Article
- Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population.International journal of chronic obstructive pulmonary disease · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundForced expiratory volume in 1s/forced expiratory volume in 6 s ( FEV1/FEV6) assessment with a microspirometer may be useful in the diagnostic work up of subjects who are suspected of having COPD in primary care.
aimTo determine the diagnostic accuracy of a negative pre-bronchodilator (BD) microspirometry test relative to a full diagnostic spirometry test in subjects in whom general practitioners (GPs) suspect airflow obstruction.
methodsCross-sectional study in which the order of microspirometry and diagnostic spirometry tests was randomised. Study subjects were (ex-)smokers aged ≥50 years referred for diagnostic spirometry to a primary care diagnostic centre by their GPs. A pre-BD FEV1/FEV6 value <0.73 as measured with the PiKo-6 microspirometer was compared with a post-BD FEV1/FVC (forced vital capacity) <0.70 and FEV1/FVC<lower limit of normal (LLN) from diagnostic spirometry.
resultsOne hundred and four subjects were analysed (59.6% males, 42.3% current smokers). Negative predictive values from microspirometry for airflow obstruction based on the fixed and LLN cut-off points were 94.4% (95% confidence interval (CI), 86.4-98.5) and 96.3% (95% CI, 88.2-99.3), respectively. In all, 18% of positive microspirometry results were not confirmed by a post-BD FEV1/FVC <0.70 and 44% of tests were false positive compared with the LLN criterion for airflow obstruction.
conclusionsPre-bronchodilator microspirometry seems to be able to reliably preselect patients for further assessment of airflow obstruction by means of regular diagnostic spirometry. However, use of microspirometry alone would result in overestimation of airflow obstruction and should not replace regular spirometry when diagnosing COPD in primary care.
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