ArticleOrganic letters2014
A general diastereoselective catalytic vinylogous aldol reaction among tetramic acid-derived pyrroles.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 16 citations in OpenAlex.
- Chemoselective Difluorination of Tetramic Acids in Water.ACS omega · 2026Article
- New Developments of the Principle of Vinylogy as Applied to π-Extended Enolate-Type Donor Systems.Chemical reviews · 2020Article
- Synthesis of Chiral Tetramic Acids: Preparation of (Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
A catalytic diastereoselective aldol reaction has been developed for N1-arylated/C2-O-silylated/C3-methylated and brominated/C4-O-methylated pyrroles in its reactions with various aldehydes. Syn adducts emerge with regard to the vicinal nitrogen and oxygen heteroatom substituents. The N1-aryl residue undergoes oxidative cleavage, and the C3-bromine atom undergoes palladium-mediated coupling reactions, both without disturbing the newly created stereocenters.
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