Evidence map›Paper›PMID 25119336›Full record

ReviewPediatric research2014

One size will never fit all: the future of research in pediatric transfusion medicine.

Cassandra D Josephson, Traci Heath Mondoro, Daniel R Ambruso, Rosa Sanchez, Steven R Sloan, Naomi L C Luban, John A Widness

Abstract readReview
In one paragraph

Review in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018
    Guideline
  2. How do we transfuse children in Italy? Results of a national survey.Blood transfusion = Trasfusione del sangue · 2025
    Article
  3. The Ratio of Intraoperative Red Blood Cell Transfusion to Blood Loss Associated with Early Postoperative Complications in Pediatric Liver Transplantation Patients.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cassandra D JosephsonDepartment of Pathology and Laboratory Medicine and Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, Georgia.
Traci Heath MondoroNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Daniel R AmbrusoBonfils Blood Center, Aurora, Colorado.
Rosa SanchezBlood Systems Research Institute, San Francisco, California.
Steven R SloanJoint Program in Transfusion Medicine, Children's Hospital, Boston, Massachusetts.
Naomi L C LubanNational Children's Medical Center, Washington, DC.
John A WidnessDepartment of Pediatrics, University of Iowa, Iowa City, Iowa.

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI NOPOULOS, PEGGY C · 1992 to 2022
$34.3M
UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
Program in Pediatric Transfusion MedicineK07HL088968 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI AMBRUSO, DANIEL R · 2007 to 2011
$648k
Pediatric Transfusion Medicine Academic Career AwardK07HL088921 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI SLOAN, STEVEN R · 2007 to 2011
$594k
Pediatric Transfusion Medicine Academic Career AwardK07HL088922 · NHLBI · EMORY UNIVERSITY · PI JOSEPHSON, CASSANDRA D · 2007 to 2011
$594k
A Multidisciplinary Approach to Education in Pediatric Transfusion MedicineK07HL088923 · NHLBI · VITALANT · PI SANCHEZ ROSEN, ROSA · 2007 to 2011
$594k
NCRR NIH HHS UL1 RR024979NCRR NIH HHS UL1RR024979NHLBI NIH HHS K07 HL088921NHLBI NIH HHS K07 HL088922NHLBI NIH HHS K07 HL088923NHLBI NIH HHS K07 HL088968NHLBI NIH HHS P01 HL046925
6 · The paper itself

Abstract

There is concern at the National Heart, Lung, and Blood Institute (NHLBI) and among transfusion medicine specialists regarding the small number of investigators and studies in the field of pediatric transfusion medicine (PTM). Accordingly, the objective of this article is to provide a snapshot of the clinical and translational PTM research considered to be of high priority by pediatricians, neonatologists, and transfusion medicine specialists. Included is a targeted review of three research areas of importance: (i) transfusion strategies, (ii) short- and long-term clinical consequences, and (iii) transfusion-transmitted infectious diseases. The recommendations by PTM and transfusion medicine specialists represent opportunities and innovative strategies to execute translational research, observational studies, and clinical trials of high relevance to PTM. With the explosion of new biomedical knowledge and increasingly sophisticated methodologies over the past decade, this is an exciting time to consider transfusion medicine as a paradigm for addressing questions related to fields such as cell biology, immunology, neurodevelopment, outcomes research, and many others. Increased awareness of PTM as an important, fertile field and the promotion of accompanying opportunities will help establish PTM as a viable career option and advance basic and clinical investigation to improve the health and wellbeing of children.

Indexed as

Age FactorsAnimalsBlood TransfusionChildChild, PreschoolDiffusion of InnovationEvidence-Based MedicineForecastingHumansInfantInfant, NewbornPediatricsRisk AssessmentRisk FactorsTransfusion ReactionTranslational Research, Biomedical

Identifiers

PMID25119336
PMCPMC4408868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.