ArticleEuropean archives of psychiatry and clinical neuroscience2015
Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder.
Article in European archives of psychiatry and clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.Brain structure & function · 2017Pooled it
- Working memory network dysfunction in bipolar I vs. bipolar II disorder: a systematic review of task-fMRI evidence.Frontiers in psychiatry · 2026Review
- The effects of amplitude modulated transcranial alternating current stimulation on working memory of college students.Frontiers in human neuroscience · 2025Article
- Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people.Molecular brain · 2024Article
- Improving working memory by electrical stimulation and cross-frequency coupling.Molecular brain · 2024Article
- The effect of bipolar bihemispheric tDCS on executive function and working memory abilities.Frontiers in psychology · 2023Article
- Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies.Translational psychiatry · 2022Review
- Working Memory and Transcranial-Alternating Current Stimulation-State of the Art: Findings, Missing, and Challenges.Frontiers in psychology · 2022Review
- The basolateral amygdala regulation of complex cognitive behaviours in the five-choice serial reaction time task.Psychopharmacology · 2019Article
- Working Memory From the Psychological and Neurosciences Perspectives: A Review.Frontiers in psychology · 2018Review
- Neonatal Amygdala Functional Connectivity at Rest in Healthy and Preterm Infants and Early Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2017Article
- Individual Differences in Adult Reading Are Associated with Left Temporo-parietal to Dorsal Striatal Functional Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Connectomic markers of disease expression, genetic risk and resilience in bipolar disorder.Translational psychiatry · 2016Article
- Classification and neurobiological concepts of mania, bipolar disorder and major depression.European archives of psychiatry and clinical neuroscience · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients suffering from bipolar affective disorder show deficits in working memory functions. In a previous functional magnetic resonance imaging study, we observed an abnormal hyperactivity of the amygdala in bipolar patients during articulatory rehearsal in verbal working memory. In the present study, we investigated the dynamic neurofunctional interactions between the right amygdala and the brain systems that underlie verbal working memory in both bipolar patients and healthy controls. In total, 18 euthymic bipolar patients and 18 healthy controls performed a modified version of the Sternberg item-recognition (working memory) task. We used the psychophysiological interaction approach in order to assess functional connectivity between the right amygdala and the brain regions involved in verbal working memory. In healthy subjects, we found significant negative functional interactions between the right amygdala and multiple cortical brain areas involved in verbal working memory. In comparison with the healthy control subjects, bipolar patients exhibited significantly reduced functional interactions of the right amygdala particularly with the right-hemispheric, i.e., ipsilateral, cortical regions supporting verbal working memory. Together with our previous finding of amygdala hyperactivity in bipolar patients during verbal rehearsal, the present results suggest that a disturbed right-hemispheric "cognitive-emotional" interaction between the amygdala and cortical brain regions underlying working memory may be responsible for amygdala hyperactivation and affects verbal working memory (deficits) in bipolar patients.
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