Evidence map›Paper›PMID 25118980›Full record

Trial reportPloS one2014

The importance of intraoperative selenium blood levels on organ dysfunction in patients undergoing off-pump cardiac surgery: a randomised controlled trial.

Ana Stevanovic, Mark Coburn, Ares Menon, Rolf Rossaint, Daren Heyland, Gereon Schälte, Thilo Werker, Willibald Wonisch, Michael Kiehntopf, Andreas Goetzenich and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01409057 (SEOPCAB), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01409057 completednot on this map

SEOPCAB: Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery

TypeobservationalSponsorRWTH Aachen UniversityRan2010 to 2012Enrolled46ConditionsSelenium Level
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Ana StevanovicDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
Mark CoburnDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
Ares MenonDepartment of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.
Rolf RossaintDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
Daren HeylandKingston General Hospital, Kingston, Ontario, Canada.
Gereon SchälteDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
Thilo WerkerDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
Willibald WonischInstitute of Physiological Chemistry, Centre for Physiological Medicine, Medical University of Graz, Graz, Austria; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Michael KiehntopfInstitute of Clinical Chemistry, Friedrich-Schiller University, Jena, Germany.
Andreas GoetzenichDepartment of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.
Steffen RexDepartment of Anaesthesiology and Department of Cardiovascular Sciences, University Hospitals Leuven, KU Leuven, Belgium.
Christian StoppeDepartment of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany; Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany; Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany.
RWTH Aachen University · DEFriedrich Schiller University Jena · DEKingston General Hospital · CAKU Leuven · BEMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCardiac surgery is accompanied by an increase of oxidative stress, a significantly reduced antioxidant (AOX) capacity, postoperative inflammation, all of which may promote the development of organ dysfunction and an increase in mortality. Selenium is an essential co-factor of various antioxidant enzymes. We hypothesized a less pronounced decrease of circulating selenium levels in patients undergoing off-pump coronary artery bypass (OPCAB) surgery due to less intraoperative oxidative stress.

methodsIn this prospective randomised, interventional trial, 40 patients scheduled for elective coronary artery bypass grafting were randomly assigned to undergo either on-pump or OPCAB-surgery, if both techniques were feasible for the single patient. Clinical data, myocardial damage assessed by myocard specific creatine kinase isoenzyme (CK-MB), circulating whole blood levels of selenium, oxidative stress assessed by asymmetric dimethylarginine (ADMA) levels, antioxidant capacity determined by glutathionperoxidase (GPx) levels and perioperative inflammation represented by interleukin-6 (IL-6) levels were measured at predefined perioperative time points.

resultsAt end of surgery, both groups showed a comparable decrease of circulating selenium concentrations. Likewise, levels of oxidative stress and IL-6 were comparable in both groups. Selenium levels correlated with antioxidant capacity (GPx: r = 0.720; p<0.001) and showed a negative correlation to myocardial damage (CK-MB: r =  -0.571, p<0.001). Low postoperative selenium levels had a high predictive value for the occurrence of any postoperative complication.

conclusionsOPCAB surgery is not associated with less oxidative stress and a better preservation of the circulating selenium pool than on-pump surgery. Low postoperative selenium levels are predictive for the development of complications.

trial registrationClinicalTrials.gov NCT01409057.

Indexed as

Oxidative StressAgedArginineBiomarkersCoronary Artery Bypass, Off-PumpCreatine Kinase, MB FormFemaleGlutathione PeroxidaseHumansInterleukin-6MaleMiddle AgedPostoperative ComplicationsPostoperative PeriodPredictive Value of TestsSeleniumArginineBiomarkersCreatine Kinase, MB FormGlutathione PeroxidaseInterleukin-6N,N-dimethylarginineSelenium

Identifiers

PMID25118980
PMCPMC4132095
OpenAlexW2057542133

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.