Evidence map›Paper›PMID 25118962›Full record

Trial reportPloS one2014

Effects of two Chinese herbal formulae for the treatment of moderate to severe stable chronic obstructive pulmonary disease: a multicenter, double-blind, randomized controlled trial.

Genfa Wang, Baojun Liu, Yuxue Cao, Yijie Du, Hongying Zhang, Qingli Luo, Bei Li, Jinfeng Wu, Yubao Lv, Jing Sun and 9 more

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Genfa WangDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Baojun LiuDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Yuxue CaoDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Yijie DuDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Hongying ZhangDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Qingli LuoDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Bei LiDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Jinfeng WuDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Yubao LvDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Jing SunDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Hualiang JinDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Kai WeiDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Zhengxiao ZhaoDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Lingwen KongDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Xianmei ZhouRespiratory Department, Jiangsu Province Hospital of TCM, Nanjing University of TCM, Nanjing, PR China.
Qing MiaoRespiratory Department, Xiyuan Hospital CACMS, Beijing, PR China.
Gang WangRespiratory Department, West China Hospital, Sichuan University, Chengdu, PR China.
Qingwei ZhouRespiratory Department, the First Hospital Affiliated to Henan University of TCM, Zhengzhou, PR China.
Jingcheng DongDepartment of integrated traditional Chinese and western medicine, Huashan Hospital, Fudan University, Shanghai, PR China; Institute of integrated traditional Chinese and western medicine of Fudan University, Shanghai, PR China.
Huashan Hospital · CNFudan University · CNFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CNJiangsu Province Hospital · CNSichuan University · CNXiyuan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aims to evaluate the efficacy and safety of two Chinese herbal formulae for the treatment of stable COPD.

methodsA multicenter, double-blind, double-dummy, and randomized controlled trial (RCT) was conducted. All groups were treated with additional conventional medicines. There were a 6-month treatment and a 12-month follow-up for 5 times. Primary outcomes included lung function test, exacerbation frequency, score of SGRQ. Second outcomes consisted of 6MWD, BODE index, psychological field score, inflammatory factors and cortisol.

resultsA total of 331 patients were randomly divided into two active treatment groups (Bushen Yiqi (BY) granule group, n = 109; Bushen Fangchuan (BF) tablet group, n = 109) and a placebo group (n = 113). Finally 262 patients completed the study. BY granule & BF tablet increased the values of VC, FEV1 (%) and FEV1/FVC (%), compared with placebo. BY granule improved PEF. Both treatments reduced acute exacerbation frequency (P = 0.067), BODE index and psychological field score, while improved 6MWD. In terms of descent rang of SGRQ score, both treatments increased (P = 0.01). Both treatments decreased inflammatory cytokines, such as IL-8, and IL-17(P = 0.0219). BY granule obviously descended IL-17(P<0.05), IL-1β (P = 0.05), IL-6, compared with placebo. They improved the level of IL-10 and cortisol. BY granule raised cortisol (P = 0.07) and decreased TNF-α. Both treatments slightly descended TGF-β1. In terms of safety, subject compliance and drug combination, there were no differences (P>0.05) among three groups.

conclusionsBY granule and BF tablet were positively effective for the treatment of COPD, and the former performed better in general.

trial registrationChinese Clinical Trial Register center ChiCTR-TRC-09000530.

Indexed as

AdultAgedDouble-Blind MethodDrugs, Chinese HerbalFemaleHumansInterleukin-10Interleukin-17Interleukin-6Interleukin-8MaleMedicine, Chinese TraditionalMiddle AgedPulmonary Disease, Chronic ObstructiveRespiratory Function TestsTransforming Growth Factor beta1Drugs, Chinese HerbalInterleukin-10Interleukin-17Interleukin-6Interleukin-8Transforming Growth Factor beta1Tumor Necrosis Factor-alpha

Identifiers

PMID25118962
PMCPMC4132093
OpenAlexW2088445409

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.