Evidence map›Paper›PMID 25118940›Full record

ArticlePsychological medicine2015

Impulsivity in disorders of food and drug misuse.

T B Mole, M A Irvine, Y Worbe, P Collins, S P Mitchell, S Bolton, N A Harrison, T W Robbins, V Voon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Reward Processing in Binge Eating and Harmful Drinking: A Systematic Review.The International journal of eating disorders · 2026
    Pooled it
  2. Impulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies.Progress in neuro-psychopharmacology & biological psychiatry · 2021
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  9. Unhealthy diets, obesity and time discounting: a systematic literature review and network analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016
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  17. An fMRI-Based Brain Marker of Individual Differences in Delay Discounting.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T B MoleDepartment of Psychiatry,University of Cambridge,Cambridge,UK.
M A IrvineDepartment of Psychiatry,University of Cambridge,Cambridge,UK.
Y WorbeBehavioural and Clinical Neuroscience Institute,University of Cambridge,Cambridge,UK.
P CollinsDepartment of Psychiatry,University of Cambridge,Cambridge,UK.
S P MitchellDepartment of Psychiatry,University of Cambridge,Cambridge,UK.
S BoltonDepartment of Psychiatry,University of Cambridge,Cambridge,UK.
N A HarrisonBrighton and Sussex Medical School,University of Sussex,Brighton,UK.
T W RobbinsBehavioural and Clinical Neuroscience Institute,University of Cambridge,Cambridge,UK.
V VoonDepartment of Psychiatry,University of Cambridge,Cambridge,UK.

Funding

Medical Research Council G0001354Wellcome Trust 093705Wellcome Trust WT093705MA
6 · The paper itself

Abstract

backgroundEvidence suggests some overlap between the pathological use of food and drugs, yet how impulsivity compares across these different clinical disorders remains unclear. Substance use disorders are commonly characterized by elevated impulsivity, and impulsivity subtypes may show commonalities and differences in various conditions. We hypothesized that obese subjects with binge-eating disorder (BED) and abstinent alcohol-dependent cohorts would have relatively more impulsive profiles compared to obese subjects without BED. We also predicted decision impulsivity impairment in obesity with and without BED.

methodThirty obese subjects with BED, 30 without BED and 30 abstinent alcohol-dependent subjects and age- and gender-matched controls were tested on delay discounting (preference for a smaller immediate reward over a larger delayed reward), reflection impulsivity (rapid decision making prior to evidence accumulation) and motor response inhibition (action cancellation of a prepotent response).

resultsAll three groups had greater delay discounting relative to healthy volunteers. Both obese subjects without BED and alcohol-dependent subjects had impaired motor response inhibition. Only obese subjects without BED had impaired integration of available information to optimize outcomes over later trials with a cost condition.

conclusionsDelay discounting appears to be a common core impairment across disorders of food and drug intake. Unexpectedly, obese subjects without BED showed greater impulsivity than obese subjects with BED. We highlight the dissociability and heterogeneity of impulsivity subtypes and add to the understanding of neurocognitive profiles across disorders involving food and drugs. Our results have therapeutic implications suggesting that disorder-specific patterns of impulsivity could be targeted.

Indexed as

Inhibition, PsychologicalAdultAlcoholismBinge-Eating DisorderDelay DiscountingFemaleHumansImpulsive BehaviorMaleMiddle AgedObesitystop signal task

Identifiers

PMID25118940
PMCPMC4998952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.