ArticleCell death & disease2014
Non-apoptotic functions of caspase-7 during osteogenesis.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Loss of Cathepsin K Impairs Collagen Biogenesis and Enhances Actin Polymerization in Trabecular Meshwork.Investigative ophthalmology & visual science · 2026Article
- Three decades of caspases and RIPKs in life and death.Human molecular genetics · 2025Review
- The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse.PloS one · 2025Article
- Caspase-9 Is a Positive Regulator of Osteoblastic Cell Migration Identified by diaPASEF Proteomics.Journal of proteome research · 2024Article
- Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024Review
- Apoptotic proteins with non-apoptotic activity: expression and function in cancer.Apoptosis : an international journal on programmed cell death · 2023Review
- Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS.International journal of molecular sciences · 2023Article
- Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis.Histochemistry and cell biology · 2022Article
- Making the head: Caspases in life and death.Frontiers in cell and developmental biology · 2022Review
- The Role of Caspase Family in Acute Brain Injury: The Potential Therapeutic Targets in the Future.Current neuropharmacology · 2022Review
- Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes.Cartilage · 2021Article
- A single-cell analytical approach to quantify activated caspase-3/7 during osteoblast proliferation, differentiation, and apoptosis.Analytical and bioanalytical chemistry · 2021Article
- Gene Expression Profiling of Apoptotic Proteins in Circulating Peripheral Blood Mononuclear Cells in Type II Diabetes Mellitus and Modulation by Metformin.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability.Biological research · 2020Article
- Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells.International journal of molecular sciences · 2020Article
- Caspase-12 Is Present During Craniofacial Development and Participates in Regulation of Osteogenic Markers.Frontiers in cell and developmental biology · 2020Article
- Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way.Cell proliferation · 2018Review
- MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells.International journal of molecular sciences · 2018Article
- FasL Modulates Expression ofFrontiers in physiology · 2018Article
- Activation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caspase-3 and -7 are generally known for their central role in the execution of apoptosis. However, their function is not limited to apoptosis and under specific conditions activation has been linked to proliferation or differentiation of specialised cell types. In the present study, we followed the localisation of the activated form of caspase-7 during intramembranous (alveolar and mandibular bones) and endochondral (long bones of limbs) ossification in mice. In both bone types, the activated form of caspase-7 was detected from the beginning of ossification during embryonic development and persisted postnatally. The bone status was investigated by microCT in both wild-type and caspase-7-deficient adult mice. Intramembranous bone in mutant mice displayed a statistically significant decrease in volume while the mineral density was not altered. Conversely, endochondral bone showed constant volume but a significant decrease in mineral density in caspase-7 knock-out mice. Cleaved caspase-7 was present in a number of cells that did not show signs of apoptosis. PCR array analysis of the mandibular bone of caspase-7-deficient versus wild-type mice pointed to a significant decrease in mRNA levels for Msx1 and Smad1 in early bone formation. These observations might explain the decrease in the alveolar bone volume of adult knock-out mice. In conclusion, this study is the first to report a non-apoptotic function of caspase-7 in osteogenesis and also demonstrates further specificities in endochondral versus intramembranous ossification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.