Evidence map›Paper›PMID 25118721›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2015

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.

S Noori, P McNamara, A Jain, P M Lavoie, A Wickremasinghe, T A Merritt, T Solomon, K Sekar, J T Attridge, J R Swanson and 7 more

Open access · greenAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Comparison of 'post-patent ductus arteriosus ligation syndrome' in premature infants after surgical ligation vs. percutaneous closure.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Article
  6. Pharmacogenomics · 2019
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 2 countries.

S Noori1] Department of Pediatrics, Children's Hospital of Los Angeles, University of South California, Los Angeles, CA, USA [2] Department of Pediatrics, University of Oklahoma, Oklahoma, OK, USA.
P McNamaraDepartment of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
A Jain1] Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada [2] Department of Pediatrics, Mount Sinai Hospital, University of Toronto, ON, Canada.
P M LavoieDepartment of Pediatrics Children's & Women's Health Centre of British Columbia, Vancouver, BC, Canada.
A WickremasingheDepartment of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
T A MerrittDepartment of Pediatrics, Loma Linda University, Loma Linda, CA, USA.
T SolomonDepartment of Pediatrics, Loma Linda University, Loma Linda, CA, USA.
K SekarDepartment of Pediatrics, University of Oklahoma, Oklahoma, OK, USA.
J T AttridgeDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.
J R SwansonDepartment of Pediatrics, University of Virginia, Charlottesville, VA, USA.
M Gillam-KrakauerDepartment of Pediatrics, Vanderbilt University, Nashville, TN, USA.
J ReeseDepartment of Pediatrics, Vanderbilt University, Nashville, TN, USA.
B B PoindexterDepartment of Pediatrics, Indiana University, Indianapolis, IN, USA.
M BrookDepartment of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
R J AuchusDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.
R I ClymanDepartment of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
PDA Ligation/Hypotension Trial Investigators
University of California, San Francisco · USUniversity of Virginia · USLoma Linda University · USChildren's Hospital of Los Angeles · USChildren's & Women's Health Centre of British Columbia · CAMount Sinai Hospital · CAHospital for Sick Children · CAUniversity of Michigan · USUniversity of Oklahoma · USVanderbilt University · USIndiana University – Purdue University Indianapolis · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Statistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1M
Genes contributing to patent ductus arteriosus susceptibility in preterm newbornsR01HL109199 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLYMAN, RONALD I · 2011 to 2014
$3.0M
Graduate Training Program in Neonatal-Perinatal Translational ResearchT32HD071860 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROWITCH, DAVID H · 2012 to 2016
$969k
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR000445-06NCRR NIH HHS UL1 RR024975NHLBI NIH HHS HL109199NHLBI NIH HHS R01 HL109199NICHD NIH HHS T32 HD071860NIDDK NIH HHS DK089503NIDDK NIH HHS P30 DK089503NIDDK NIH HHS U24 DK097153NIDDK NIH HHS U24DK097153
6 · The paper itself

Abstract

objectiveWe performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation. STUDY

designA standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was > 15 μg kg(-1)min(-1). Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension).

resultForty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration.

conclusionWe speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.

Indexed as

DopamineHypotensionPostoperative ComplicationsCardiac Surgical ProceduresCardiotonic AgentsCatecholaminesDobutamineDrug ResistanceDuctus Arteriosus, PatentEchocardiographyFemaleHumansInfant, NewbornInfant, PrematureLigationMaleCardiotonic AgentsCatecholaminesDobutamineDopamine

Identifiers

PMID25118721
PMCPMC4310792
OpenAlexW2073272508

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.