ArticleAnnals of biomedical engineering2015
Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 4D-flow MRI derived wall shear stress for the risk stratification of bicuspid aortic valve aortopathy: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Article
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Expanding the volume on 4D flow CMR : Editorial for "Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve".The international journal of cardiovascular imaging · 2025Article
- Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve.The international journal of cardiovascular imaging · 2025Article
- Differences in Pulmonary Artery Flow Hemodynamics Between PAH and PH-HFpEF: Insights From 4D-Flow CMR.Pulmonary circulation · 2025Article
- Multiyear Interval Changes in Aortic Wall Shear Stress in Patients with Bicuspid Aortic Valve Assessed by 4D Flow MRI.Journal of magnetic resonance imaging : JMRI · 2024Article
- Blood flow assessment technology in aortic surgery: a narrative review.Journal of thoracic disease · 2024Review
- Hemodynamic parameters impact the stability of distal stent graft-induced new entry.Scientific reports · 2023Article
- Clinical Use of Blood Flow Analysis through 4D-Flow Imaging in Aortic Valve Disease.Journal of cardiovascular development and disease · 2023Review
- Systolic reverse flow derived from 4D flow cardiovascular magnetic resonance in bicuspid aortic valve is associated with aortic dilation and aortic valve stenosis: a cross sectional study in 655 subjects.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Changes of aortic hemodynamics after aortic valve replacement-A four dimensional flow cardiovascular magnetic resonance follow up study.Frontiers in cardiovascular medicine · 2023Article
- Article
- Wall Shear Stress Estimation for 4D Flow MRI Using Navier-Stokes Equation Correction.Annals of biomedical engineering · 2022Article
- Abdominal applications of quantitative 4D flow MRI.Abdominal radiology (New York) · 2022Review
- 4D flow MRI derived aortic hemodynamics multi-year follow-up in repaired coarctation with bicuspid aortic valve.Diagnostic and interventional imaging · 2022Article
- The genetic, molecular, and hemodynamic basis of bicuspid aortic valve aortopathy: A contemporary narrative review.International journal of cardiology. Congenital heart disease · 2022Review
- The Role of Cardiac Magnetic Resonance in Aortic Stenosis and Regurgitation.Journal of cardiovascular development and disease · 2022Review
- Improving transcatheter aortic valve interventional predictability via fluid-structure interaction modelling using patient-specific anatomy.Royal Society open science · 2022Article
- A multi-modality approach for enhancing 4D flow magnetic resonance imaging via sparse representation.Journal of the Royal Society, Interface · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
There exists considerable controversy surrounding the timing and extent of aortic resection for patients with BAV disease. Since abnormal wall shear stress (WSS) is potentially associated with tissue remodeling in BAV-related aortopathy, we propose a methodology that creates patient-specific 'heat maps' of abnormal WSS, based on 4D flow MRI. The heat maps were created by detecting outlier measurements from a volumetric 3D map of ensemble-averaged WSS in healthy controls. 4D flow MRI was performed in 13 BAV patients, referred for aortic resection and 10 age-matched controls. Systolic WSS was calculated from this data, and an ensemble-average and standard deviation (SD) WSS map of the controls was created. Regions of the individual WSS maps of the BAV patients that showed a higher WSS than the mean + 1.96SD of the ensemble-average control WSS map were highlighted. Elevated WSS was found on the greater ascending aorta (35% ± 15 of the surface area), which correlated significantly with peak systolic velocity (R (2) = 0.5, p = 0.01) and showed good agreement with the resected aortic regions. This novel approach to characterize regional aortic WSS may allow clinicians to gain unique insights regarding the heterogeneous expression of aortopathy and may be leveraged to guide patient-specific resection strategies for aorta repair.
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