ArticleLasers in medical science2015
Are the mitochondrial respiratory complexes blocked by NO the targets for the laser and LED therapy?
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Contrasting biological responses of gingival fibroblasts and keratinocyte to blue and violet light irradiation: implications for photobiomodulation use in the therapeutic management of periodontal disease.Lasers in medical science · 2026Article
- Photobiomodulation with Blue Light on Wound Healing: A Scoping Review.Life (Basel, Switzerland) · 2023Article
- Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2019Article
- Cold water immersion or LED therapy after training sessions: effects on exercise-induced muscle damage and performance in rats.Lasers in medical science · 2019Article
- Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study.Lasers in medical science · 2018Article
- Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide.Frontiers in medicine · 2018Review
- Age-related adaptive responses of mitochondria of the retinal pigment epithelium to the everyday blue LED lighting.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2017Article
- Metabolic activity of odontoblast-like cells irradiated with blue LED (455 nm).Lasers in medical science · 2016Article
- Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis.Lasers in medical science · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of laser (442 and 532 nm) and light-emitting diode (LED) (650 nm) radiation on mitochondrial respiration and mitochondrial electron transport rate (complexes II-III and IV) in the presence of nitric oxide (NO) were investigated. It was found that nitric oxide (300 nM-10 μM) suppresses mitochondrial respiration. Laser irradiation of mitochondria (442 nm, 3 J cm(-2)) partly restored mitochondrial respiration (approximately by 70 %). Irradiation with green laser (532 nm) or red LED (650 nm) in the same dose had no reliable effect. Evaluation of mitochondrial electron transport rate in complexes II-III and IV and effects of nitric oxide demonstrated almost similar sensitivity of complex II-III and IV to NO, with approximately 50 % inhibition at NO concentration of 3 μM. Subsequent laser or LED irradiation (3 J cm(-2)) showed partial recovery of electron transport only in complex IV and only under irradiation with blue light (442 nm). Our results support the hypothesis of the crucial role of cytochrome c oxidase (complex IV) in photoreactivation of mitochondrial respiration suppressed by NO.
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