ArticlePlant physiology2014
Root-secreted nicotianamine from Arabidopsis halleri facilitates zinc hypertolerance by regulating zinc bioavailability.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 88 citations in OpenAlex.
- Analysis of the TaNAS gene family in bread wheat identifies additional members and candidates for intragenic biofortification.Journal of experimental botany · 2026Article
- CRISPR/Cas9-mediated knockout of ZmHMA3 reveals its essential role in zinc homeostasis and high-zinc stress tolerance in maize.Scientific reports · 2026Article
- Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese.iScience · 2025Article
- Overexpression of aInternational journal of molecular sciences · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Transcriptome analysis revealed key genes and pathways related to cadmium tolerance and accumulation in coix (Frontiers in plant science · 2025Article
- Arsenic stress triggers active exudation of arsenic-phytochelatin complexes from Lupinus albus roots.Journal of experimental botany · 2024Article
- The Role of Low-Molecular-Weight Organic Acids in Metal Homeostasis in Plants.International journal of molecular sciences · 2024Review
- Conservative mechanism through various rapeseed (Frontiers in plant science · 2024Article
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- Duckweed: a potential phytosensor for heavy metals.Plant cell reports · 2022Review
- The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients.Plants (Basel, Switzerland) · 2022Review
- Effect of Separate and Combined Toxicity of Bisphenol A and Zinc on the Soil Microbiome.International journal of molecular sciences · 2022Article
- Zinc toxicity response inFrontiers in plant science · 2022Article
- Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation.Photosynthesis research · 2021Review
- Comparative understanding of metal hyperaccumulation in plants: a mini-review.Environmental geochemistry and health · 2021Review
- Zinc Hyperaccumulation in Plants: A Review.Plants (Basel, Switzerland) · 2020Review
- Zinc Excess Induces a Hypoxia-Like Response by Inhibiting Cysteine Oxidases in Poplar Roots.Plant physiology · 2019Article
- Effect of water cadmium concentration and water level on the growth performance of Salix triandroides cuttings.Environmental science and pollution research international · 2018Article
- Recent strategies of increasing metal tolerance and phytoremediation potential using genetic transformation of plants.Plant biotechnology reports · 2018Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperaccumulators tolerate and accumulate extraordinarily high concentrations of heavy metals. Content of the metal chelator nicotianamine (NA) in the root of zinc hyperaccumulator Arabidopsis halleri is elevated compared with nonhyperaccumulators, a trait that is considered to be one of the markers of a hyperaccumulator. Using metabolite-profiling analysis of root secretions, we found that excess zinc treatment induced secretion of NA in A. halleri roots compared with the nonhyperaccumulator Arabidopsis thaliana. Metal speciation analysis further revealed that the secreted NA forms a stable complex with Zn(II). Supplying NA to a nonhyperaccumulator species markedly increased plant zinc tolerance by decreasing zinc uptake. Therefore, NA secretion from A. halleri roots facilitates zinc hypertolerance through forming a Zn(II)-NA complex outside the roots to achieve a coordinated zinc uptake rate into roots. Secretion of NA was also found to be responsible for the maintenance of iron homeostasis under excess zinc. Together our results reveal root-secretion mechanisms associated with hypertolerance and hyperaccumulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.