Evidence map›Paper›PMID 25118030›Full record

ReviewEuropean journal of human genetics : EJHG2015

Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification.

Muriel de La Dure-Molla, Benjamin Philippe Fournier, Ariane Berdal

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of human genetics : EJHG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. The genetics of non-syndromic dentinogenesis imperfecta: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Pooled it
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  4. [Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  5. Article
  6. Reports (MDPI) · 2026
    Article
  7. Review
  8. Genes & diseases · 2026
    Article
  9. [Case report of dentinogenesis imperfecta and review of literature].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Review
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  20. Vole genomics links determinate and indeterminate growth of teeth.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Muriel de La Dure-Molla1] Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratory of Molecular Oral Pathophysiology, Paris, France [2] Paris-Descartes University, Paris, France [3] The Pierre-and-Marie-Curie University, Paris, France [4] Paris-Diderot, School of Dentistry, Paris, France [5] Reference Center for Dental Rare Disease, MAFACE Rothschild Hospital, AP-HP, Paris, France.
Benjamin Philippe Fournier1] Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratory of Molecular Oral Pathophysiology, Paris, France [2] Paris-Descartes University, Paris, France [3] The Pierre-and-Marie-Curie University, Paris, France [4] Paris-Diderot, School of Dentistry, Paris, France [5] Reference Center for Dental Rare Disease, MAFACE Rothschild Hospital, AP-HP, Paris, France.
Ariane Berdal1] Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratory of Molecular Oral Pathophysiology, Paris, France [2] Paris-Descartes University, Paris, France [3] The Pierre-and-Marie-Curie University, Paris, France [4] Paris-Diderot, School of Dentistry, Paris, France [5] Reference Center for Dental Rare Disease, MAFACE Rothschild Hospital, AP-HP, Paris, France.
Inserm · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dentinogenesis imperfecta is an autosomal dominant disease characterized by severe hypomineralization of dentin and altered dentin structure. Dentin extra cellular matrix is composed of 90% of collagen type I and 10% of non-collagenous proteins among which dentin sialoprotein (DSP), dentin glycoprotein (DGP) and dentin phosphoprotein (DPP) are crucial in dentinogenesis. These proteins are encoded by a single gene: dentin sialophosphoprotein (DSPP) and undergo several post-translational modifications such as glycosylation and phosphorylation to contribute and to control mineralization. Human mutations of this DSPP gene are responsible for three isolated dentinal diseases classified by Shield in 1973: type II and III dentinogenesis imperfecta and type II dentin dysplasia. Shield classification was based on clinical phenotypes observed in patient. Genetics results show now that these three diseases are a severity variation of the same pathology. So this review aims to revise and to propose a new classification of the isolated forms of DI to simplify diagnosis for practitioners.

Indexed as

Collagen Type IDentinDentin DysplasiaDentinogenesis ImperfectaDentin SialophosphoproteinExtracellular Matrix ProteinsGenetic VariationHumansMutationPhenotypePhosphoproteinsSialoglycoproteinsCollagen Type IDentin SialophosphoproteinExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteins

Identifiers

PMID25118030
PMCPMC4666581
OpenAlexW1966172763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.