Evidence map›Paper›PMID 25117965›Full record

ReviewJournal of acquired immune deficiency syndromes (1999)2014

HIV, tuberculosis, and noncommunicable diseases: what is known about the costs, effects, and cost-effectiveness of integrated care?

Emily P Hyle, Kogieleum Naidoo, Amanda E Su, Wafaa M El-Sadr, Kenneth A Freedberg

Abstract readReview
In one paragraph

Review in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Use of integrated services in antenatal care: A case study of Mabvuku Polyclinic, Zimbabwe.African journal of primary health care & family medicine · 2025
    Article
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  16. Estimating the Cost of Delivering Tobacco Cessation Intervention Package at Noncommunicable Disease Clinics in Two Districts of North India.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily P Hyle*Harvard Medical School, Boston, MA; †Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA; ‡Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA; §Division of General Medicine, Massachusetts General Hospital, Boston, MA; ‖Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa; ¶International Center for AIDS Care and Treatment Programs (ICAP), Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY; #Center for AIDS Research (CFAR), Harvard University, Boston, MA; **Department of Epidemiology, Boston University, Boston, MA; and ††Department of Health Policy and Management, Harvard School of Public Health, Boston, MA.
Kogieleum Naidoo
Amanda E Su
Wafaa M El-Sadr
Kenneth A Freedberg

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
HIV Prevention trials Network (HPTN) Coordinating and Operations CenterU01AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI VERMUND, STEN H. · 2006 to 2010
$72.7M
The Viral Set Point in HIV-1 Subtype C InfectionU19AI051794 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI ABDOOL KARIM, SALIM S · 2002 to 2007
$22.5M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
TUBERCULOSIS SUPPLEMENTD43TW000231 · FIC · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ABDOOL KARIM, QUARRAISHA · 1993 to 2014
$13.1M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
FIC NIH HHS D43 TW000231NIAID NIH HHS 3 U19 AI051794NIAID NIH HHS P30 AI060354NIAID NIH HHS P30AI060354NIAID NIH HHS R01 AI058736NIAID NIH HHS R01AI058736NIAID NIH HHS T32 AI007433NIAID NIH HHS U19 AI051794NIAID NIH HHS UM1 AI068619
6 · The paper itself

Abstract

Unprecedented investments in health systems in low- and middle-income countries (LMICs) have resulted in more than 8 million individuals on antiretroviral therapy. Such individuals experience dramatically increased survival but are increasingly at risk of developing common noncommunicable diseases (NCDs). Integrating clinical care for HIV, other infectious diseases, and NCDs could make health services more effective and provide greater value. Cost-effectiveness analysis is a method to evaluate the clinical benefits and costs associated with different health care interventions and offers guidance for prioritization of investments and scale-up, especially as resources are increasingly constrained. We first examine tuberculosis and HIV as 1 example of integrated care already successfully implemented in several LMICs; we then review the published literature regarding cervical cancer and depression as 2 examples of NCDs for which integrating care with HIV services could offer excellent value. Direct evidence of the benefits of integrated services generally remains scarce; however, data suggest that improved effectiveness and reduced costs may be attained by integrating additional services with existing HIV clinical care. Further investigation into clinical outcomes and costs of care for NCDs among people living with HIV in LMICs will help to prioritize specific health care services by contributing to an understanding of the affordability and implementation of an integrated approach.

Indexed as

Cost-Benefit AnalysisDelivery of Health Care, IntegratedDepressionDeveloping CountriesFemaleHIV InfectionsHumansTreatment OutcomeTuberculosisUterine Cervical Neoplasms

Identifiers

PMID25117965
PMCPMC4147396

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.