ArticleEuropean journal of neurology2015
Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study.
Article in European journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Vitamin D and Cognitive Impairment.Nutrients · 2025Article
- The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: cross-sectional and longitudinal analyses.The American journal of clinical nutrition · 2024Article
- Current Evidence on the Association of Micronutrient Malnutrition with Mild Cognitive Impairment, Frailty, and Cognitive Frailty among Older Adults: A Scoping Review.International journal of environmental research and public health · 2022Article
- Cognitive Status and Nutritional Markers in a Sample of Institutionalized Elderly People.Frontiers in aging neuroscience · 2022Article
- Investigating Potential Dose-Response Relationships between Vitamin D Status and Cognitive Performance: A Cross-Sectional Analysis in Middle- to Older-Aged Adults in the Busselton Healthy Ageing Study.International journal of environmental research and public health · 2021Article
- Vitamin D and Folate as Predictors of MMSE in Alzheimer's Disease: A Machine Learning Analysis.Diagnostics (Basel, Switzerland) · 2021Article
- The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study.Nutrients · 2020Article
- Vitamin D status, cognitive decline and incident dementia: the Canadian Study of Health and Aging.Canadian journal of public health = Revue canadienne de sante publique · 2020Article
- Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study.BMC nutrition · 2020Article
- Low Vitamin D and Its Association with Cognitive Impairment and Dementia.Journal of aging research · 2020Review
- Attenuated serum 25-hydroxyvitamin D and vitamin D binding protein associated with cognitive impairment in patients with type 2 diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Higher Vitamin D Levels Are Associated with Better Attentional Functions: Data from the NorCog Register.The journal of nutrition, health & aging · 2019Article
- Nutrition in the Very Old.Nutrients · 2018Review
- One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study.Journal of the American Medical Directors Association · 2017Article
- Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study.European journal of nutrition · 2017Article
- Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.Nutrients · 2017Observational
- Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia.Frontiers in aging neuroscience · 2017Article
- Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults.European journal of nutrition · 2016Article
- Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
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Funding
Abstract
background and purposeStudies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking.
methodsCross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by the Standardized Mini-Mental State Examination) and attention-specific (measured by the attention battery of the Cognitive Drug Research test) cognitive performance in relation to season-specific 25(OH)D quartiles.
resultsThose in the lowest and highest season-specific 25(OH)D quartiles had an increased risk of impaired prevalent (1.66, 95% confidence interval 1.06-2.60, P = 0.03; 1.62, 95% confidence interval 1.02-2.59, P = 0.04, respectively) but not incident global cognitive functioning or decline in functioning compared with those in the middle quartiles adjusted for sociodemographic, health and lifestyle confounders. Random effects models showed that participants belonging to the lowest and highest 25(OH)D quartiles, compared with those in the middle quartiles, had overall slower (log-transformed) attention reaction times for Choice Reaction Time (lowest, β = 0.023, P = 0.01; highest, β = 0.021, P = 0.02), Digit Vigilance Task (lowest, β = 0.009, P = 0.05; highest, β = 0.01, P = 0.02) and Power of Attention (lowest, β = 0.017, P = 0.02; highest, β = 0.022, P = 0.002) and greater Reaction Time Variability (lowest, β = 0.021, P = 0.02; highest, β = 0.02, P = 0.03). The increased risk of worse global cognition and attention amongst those in the highest quartile was not observed in non-users of vitamin D supplements/medication.
conclusionLow and high season-specific 25(OH)D quartiles were associated with prevalent cognitive impairment and poorer overall performance in attention-specific tasks over 3 years in the very old, but not with global cognitive decline or incident impairment.
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