ArticleBrain connectivity2014
Interhemispheric plasticity protects the deafferented somatosensory cortex from functional takeover after nerve injury.
Article in Brain connectivity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Reactivated thalamocortical plasticity alters neural activity in sensory-motor cortex during post-critical period.Progress in neurobiology · 2025Article
- Behavioral adaptations after unilateral whisker denervation.Behavioural brain research · 2025Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Peripheral Nerve Injury Induces Changes in the Activity of Inhibitory Interneurons as Visualized in Transgenic GAD1-GCaMP6s Rats.Biosensors · 2022Article
- Dysfunction in the Interaction of Information Between and Within the Bilateral Primary Sensory Cortex.Frontiers in aging neuroscience · 2022Article
- Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Interhemispheric plasticity is mediated by maximal potentiation of callosal inputs.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs.Cell reports · 2017Article
- Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity.Brain stimulationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Functional changes across brain hemispheres have been reported after unilateral cortical or peripheral nerve injury. Interhemispheric callosal connections usually underlie this cortico-cortical plasticity. However, the effect of the altered callosal inputs on local cortical plasticity in the adult brain is not well studied. Ipsilateral functional magnetic resonance imaging (fMRI) activation has been reliably detected in the deafferented barrel cortex (BC) at 2 weeks after unilateral infraorbital denervation (IO) in adult rats. The ipsilateral fMRI signal relies on callosal-mediated interhemispheric plasticity. This form of interhemispheric plasticity provides a good chronic model to study the interaction between callosal inputs and local cortical plasticity. The receptive field of forepaw in the primary somatosensory cortex (S1), which is adjacent to the BC, was mapped with fMRI. The S1 receptive field expanded to take over a portion of the BC in 2 weeks after both ascending inputs and callosal inputs were removed in IO rats with ablated contralateral BC (IO+ablation). This expansion, estimated specifically by fMRI mapping, is significantly larger than what has been observed in the IO rats with intact callosal connectivity, as well as in the rats with sham surgery. This work indicates that altered callosal inputs prevent the functional takeover of the deafferented BC from adjacent cortices and may help preserve the functional identity of the BC.
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