ArticleNeurobiology of learning and memory2014
Characterization of the rapid transcriptional response to long-term sensitization training in Aplysia californica.
Article in Neurobiology of learning and memory, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Transcriptional Changes Fade Prior to Long-Term Memory for Sensitization of thebioRxiv : the preprint server for biology · 2025Article
- ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica.Neurobiology of learning and memory · 2018Article
- Savings memory is accompanied by transcriptional changes that persist beyond the decay of recall.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- AfterJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2017Article
- Immediate and persistent transcriptional correlates of long-term sensitization training at different CNS loci in Aplysia californica.PloS one · 2014Article
- Transcriptional analysis of a whole-body form of long-term habituation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We used a custom-designed microarray and quantitative PCR to characterize the rapid transcriptional response to long-term sensitization training in the marine mollusk Aplysia californica. Aplysia were exposed to repeated noxious shocks to one side of the body, a procedure known to induce a long-lasting, transcription-dependent increase in reflex responsiveness that is restricted to the side of training. One hour after training, pleural ganglia from the trained and untrained sides of the body were harvested; these ganglia contain the sensory nociceptors which help mediate the expression of long-term sensitization memory. Microarray analysis from 8 biological replicates suggests that long-term sensitization training rapidly regulates at least 81 transcripts. We used qPCR to test a subset of these transcripts and found that 83% were confirmed in the same samples, and 86% of these were again confirmed in an independent sample. Thus, our new microarray design shows strong convergent and predictive validity for analyzing the transcriptional correlates of memory in Aplysia. Fully validated transcripts include some previously identified as regulated in this paradigm (ApC/EBP and ApEgr) but also include novel findings. Specifically, we show that long-term sensitization training rapidly up-regulates the expression of transcripts which may encode Aplysia homologs of a C/EBPγ transcription factor, a glycine transporter (GlyT2), and a vacuolar-protein-sorting-associated protein (VPS36).
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