Evidence map›Paper›PMID 25117570›Full record

ArticleEndocrine connections2014

Liver status in congenital, untreated, isolated GH deficiency.

Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa and 8 more

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In one paragraph

Article in Endocrine connections, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Rachel D C A DinizDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Renata M SouzaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Roberto SalvatoriDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil salvator@jhmi.edu.
Alex FrancaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Elenilde Gomes-SantosDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Thiago O FerrãoDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Carla R P OliveiraDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
João A M SantanaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Francisco A PereiraDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Rita A A BarbosaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Anita H O SouzaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Rossana M C PereiraDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Alécia A Oliveira-SantosDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Allysson M P SilvaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Francisco J Santana-JúniorDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Eugênia H O ValençaDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Viviane C CamposDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Manuel H Aguiar-OliveiraDivision of EndocrinologyDiabetes and Metabolism, Federal University of Sergipe, Aracaju, BrazilDivision of EndocrinologyDiabetes and Metabolism, the Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, Maryland 21287, USADivision of HepatologyDivision of RadiologyFederal University of Sergipe, Aracaju, Brazil.
Universidade Federal de Sergipe · BRJohns Hopkins Medicine · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2013 to 2017
$9.7M
NIDDK NIH HHS P30 DK079637
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is known to be associated with insulin resistance, atherosclerosis, and low serum IGF1 levels. We have described a large cohort of patients with isolated GH deficiency (IGHD) due to the c.57+1G→A mutation in the GHRH receptor gene. These subjects have increased insulin sensitivity (IS), delayed atherosclerosis, and normal longevity. We hypothesized that, despite visceral obesity, NAFLD would be absent or mild due to the increased IS. To assess the prevalence and severity of NAFLD in adult subjects with lifetime, congenital, untreated IGHD, we studied 22 IGHD adults and 25 controls (COs) matched for age and sex. NAFLD was assessed by a comprehensive liver function panel, and ultrasonographic pattern (hyperechogenic pattern, HP) coded as follows: 0, absent; 1, mild; 2, moderate; and 3, severe. Compared with COs, IGHD individual had lower serum IGF1 (P<0.0001), higher total cholesterol (P=0.027), lower prothrombin time (P=0.017), and similar activated partial thromboplastin time and fibrinogen values. Alanine transaminase (ALT) values were similar in the two groups, but aspartate transaminase was higher in IGHD (P=0.013). However, more IGHD subjects (7/22) than COs (3/23) had ALT above the upper limit of normal (P=0.044). The prevalence of NAFLD was higher in IGHD than COs (61 vs 29%, P=0.032), and the HP score was higher in IGHD than COs (P=0.041), but severe NAFLD was not observed in any IGHD (or CO) individual. Liver HP score is increased in lifetime, untreated, congenital IGHD, but the increase in transaminases is mild, suggesting a lack of advanced forms of NAFLD.

Indexed as

GHIGF1isolated GH deficiencyNAFLD

Identifiers

PMID25117570
PMCPMC4151384
OpenAlexW2166795723

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.