ArticleNeurotoxicology2014
Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity.
Article in Neurotoxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Manganese Exposure: Delayed Effects and Biomarkers in adult male and female Wistar rats.Molecular neurobiology · 2026Article
- Manganese-induced damage to the serotoninergic system is associated with the development of anxiety and depression.Toxicology reports · 2025Article
- Manganese Overexposure Alters Neurogranin Expression and Causes Behavioral Deficits in Larval Zebrafish.International journal of molecular sciences · 2024Article
- Neuroprotective Effect of Resveratrol against Manganese-Induced Oxidative Stress and Matrix Metalloproteinase-9 in an "In Vivo" Model of Neurotoxicity.International journal of molecular sciences · 2024Article
- An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents.Environmental health perspectives · 2024Article
- Assessing the mediating role of iron status on associations between an industry-relevant metal mixture and verbal learning and memory in Italian adolescents.The Science of the total environment · 2024Article
- Trace Metal Accumulation in Rats Exposed to Mine Waters: A Case Study, Bor Area (Serbia).Toxics · 2023Article
- Lipid metabolism in dopaminergic neurons influences light entrainment.Journal of neurochemistry · 2023Article
- Associations of an industry-relevant metal mixture with verbal learning and memory in Italian adolescents: The modifying role of iron status.Environmental research · 2023Article
- N-Acetylcysteine Ameliorates Neurotoxic Effects of Manganese Intoxication in Rats: A Biochemical and Behavioral Study.Neurochemical research · 2021Article
- MR T1 mapping for quantifying brain manganese deposition in type C hepatic encephalopathy rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Defective Mitochondrial Dynamics Underlie Manganese-Induced Neurotoxicity.Molecular neurobiology · 2021Article
- Involvement of MEK5/ERK5 signaling pathway in manganese-induced cell injury in dopaminergic MN9D cells.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020Article
- Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats.Neurochemical research · 2020Article
- Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity.The Journal of nutrition · 2020Article
- Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure.International journal of environmental research and public health · 2018Article
- Subchronic Manganese Exposure Impairs Neurogenesis in the Adult Rat Hippocampus.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure.Toxicology letters · 2018Article
- Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility.Environment international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Manganese (Mn) is an essential trace element, but excess exposure leads to accumulation in biological tissues, including the brain. Chronically high Mn levels in the brain are neurotoxic and can result in a progressive, irreversible neurological disorder known as manganism. Manganism has signs and symptoms similar to, but distinguishable from idiopathic Parkinson's disease, which include both psychological and motor disturbances. Evidence suggests that Mn exposure impacts neurotransmitter levels in the brain. However, it remains unclear if subacute, low-level Mn exposure resulted in alterations in neurotransmitter systems with concomitant behavioral deficits. The current study used high performance liquid chromatography to quantify neurotransmitter levels in rat striatum (STR), substantia nigra (SN), and hippocampus (HP). Subacute Mn exposure via i.p. injection of 15mg Mn/kg as MnCl2 caused significantly increased dopamine (DA) levels in the STR. The enhancement was accompanied by significantly elevated levels of the DA metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the STR. In addition, levels of HVA were significantly increased in the SN and HP. These data indicate that subacute, low-level Mn exposure disrupts multiple neurotransmitter systems in the rat brain which may be responsible, in part, for observed locomotor deficits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.