ArticleAmerican journal of human genetics1989
The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.
Article in American journal of human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.Molecular human reproduction · 2023Article
- ZFX regulates glioma cell proliferation and survival in vitro and in vivo.Journal of neuro-oncology · 2013Article
- Association of MAOA, 5-HTT, and NET promoter polymorphisms with gene expression and protein activity in human placentas.Physiological genomics · 2010Article
- An autosomal or X linked mutation results in true hermaphrodites and 46,XX males in the same family.Journal of medical genetics · 1998Review
- Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX.Nucleic acids research · 1996Article
- A Bkm-associated human y-chromosomal DNA is conserved and transcribed in the testis of mouse.Chromosoma · 1995Article
- A ZFY-like sequence in fish, with comments on the evolution of the ZFY family of genes in vertebrates.Biochemical genetics · 1995Article
- Isodicentric Y chromosome: cytogenetic, molecular and clinical studies and review of the literature.Human genetics · 1995Review
- SRVX, a sex reversing locus in Xp21.2-->p22.11.Human genetics · 1994Article
- Sex determination by low stringency PCR (LS-PCR).Nucleic acids research · 1993Article
- Cytogenetic and molecular characterization of marker chromosomes in patients with mosaic 45,X karyotypes.Human genetics · 1992Article
- A mouse Y chromosome pseudogene is related to human ubiquitin activating enzyme E1.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- An X-linked zinc finger gene mapping to Xq21.1-q21.3 closely related to ZFX and ZFY: possible origins from a common ancestral gene.Nucleic acids research · 1991Article
- Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.Nucleic acids research · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The zinc-finger-Y (ZFY) gene is a candidate for the testis-determining-factor gene (TDF) on the human Y chromosome and is postulated to initiate testis differentiation during embryogenesis. However, the present study indicates that the ZFY gene and its X homologue (ZFX) are differentially expressed in adult tissues. A human testis-specific ZFY cDNA was isolated and completely sequenced. The corresponding ZFY transcript encodes a protein that has 801 amino acids and a calculated molecular weight of 90.6 kD. Expression analysis demonstrated that ZFY is transcribed primarily as 3- and 5.7-kb mRNA in testis and somatic cells, respectively. In contrast, the ZFX gene is expressed as a 5-kb transcript in the testis and as 6.7- and 8-kb transcripts in both ovarian and somatic tissues. With sets of gene-specific oligonucleotides, the origin and relative amount of the respective transcripts can be demonstrated in both Northern hybridization and reverse transcriptase-polymerase chain reaction analysis. Significantly, the 3-kb ZFY transcript was also detected in other mammalian adult testes. The testis-specific transcription of the ZFY gene hence suggests that it serves a conserved function in this organ.
Indexed as
Identifiers
2511751PMC1683462W2219488575What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.