Evidence map›Paper›PMID 25117497›Full record

ReviewProgress in biophysics and molecular biology2014

Images as drivers of progress in cardiac computational modelling.

Pablo Lamata, Ramón Casero, Valentina Carapella, Steve A Niederer, Martin J Bishop, Jürgen E Schneider, Peter Kohl, Vicente Grau

Abstract readReview
In one paragraph

Review in Progress in biophysics and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Cardio-Rheumatic Diseases: Inflammasomes Behaving Badly.International journal of molecular sciences · 2025
    Review
  2. A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff-Parkinson-White syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  3. Review
  4. Article
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  7. Article
  8. Review
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  11. Cardiac multi-scale investigation of the right and left ventricleCardiovascular diagnosis and therapy · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Optimization Framework for Patient-Specific Cardiac Modeling.Cardiovascular engineering and technology · 2019
    Article
  17. Article
  18. Computational models in cardiology.Nature reviews. Cardiology · 2019
    Review
  19. Position Paper Computational Cardiology.IEEE journal of biomedical and health informatics · 2019
    Article
  20. Efficient estimation of personalized biventricular mechanical function employing gradient-based optimization.International journal for numerical methods in biomedical engineering · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pablo LamataDept. Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College of London, London, United Kingdom; Dept. Computer Science, University of Oxford, Oxford, United Kingdom. Electronic address: Pablo.Lamata@kcl.ac.uk.
Ramón CaseroInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
Valentina CarapellaDept. Computer Science, University of Oxford, Oxford, United Kingdom.
Steve A NiedererDept. Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College of London, London, United Kingdom.
Martin J BishopDept. Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College of London, London, United Kingdom.
Jürgen E SchneiderRadcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Peter KohlNational Heart and Lung Institute, Imperial College, London, United Kingdom; Dept. Computer Science, University of Oxford, Oxford, United Kingdom.
Vicente GrauInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BBSRC BB/I012117/1British Heart Foundation FS/11/50/29038British Heart Foundation FS/12/17/29532British Heart Foundation NH/13/1/30238British Heart Foundation PG/11/101/29212British Heart Foundation PG/13/37/30280Wellcome Trust 099973Wellcome Trust WT 088641/Z/09/Z
6 · The paper itself

Abstract

Computational models have become a fundamental tool in cardiac research. Models are evolving to cover multiple scales and physical mechanisms. They are moving towards mechanistic descriptions of personalised structure and function, including effects of natural variability. These developments are underpinned to a large extent by advances in imaging technologies. This article reviews how novel imaging technologies, or the innovative use and extension of established ones, integrate with computational models and drive novel insights into cardiac biophysics. In terms of structural characterization, we discuss how imaging is allowing a wide range of scales to be considered, from cellular levels to whole organs. We analyse how the evolution from structural to functional imaging is opening new avenues for computational models, and in this respect we review methods for measurement of electrical activity, mechanics and flow. Finally, we consider ways in which combined imaging and modelling research is likely to continue advancing cardiac research, and identify some of the main challenges that remain to be solved.

Indexed as

Models, CardiovascularAnimalsComputer SimulationDiagnostic ImagingExcitation Contraction CouplingHeart Conduction SystemHumansMyocardial ContractionVentricular FunctionComputational cardiac physiologyMedical imaging

Identifiers

PMID25117497
PMCPMC4210662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.