Evidence map›Paper›PMID 25117461›Full record

ArticleEuropean journal of endocrinology2014

Alcohol and the risk for latent autoimmune diabetes in adults: results based on Swedish ESTRID study.

Bahareh Rasouli, Tomas Andersson, Per-Ola Carlsson, Mozhgan Dorkhan, Valdemar Grill, Leif Groop, Mats Martinell, Tiinamaja Tuomi, Sofia Carlsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Alcohol Consumption and Autoimmune Diseases.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Adult-onset autoimmune diabetes.Nature reviews. Disease primers · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Bahareh RasouliEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland bahareh.rasouli@ki.se.
Tomas AnderssonEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland Epidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Per-Ola CarlssonEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Mozhgan DorkhanEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Valdemar GrillEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Leif GroopEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Mats MartinellEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Tiinamaja TuomiEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Sofia CarlssonEpidemiology UnitInstitute of Environmental Medicine (IMM), Karolinska Institutet, SE 171 77 Stockholm, SwedenCenter for Occupational and Environmental MedicineStockholm County Council, Stockholm, SwedenDepartment of Medical SciencesUppsala University, SE-751 85 Uppsala, SwedenDepartment of Clinical Sciences in MalmöClinical Research Centre, Lund University, SE-205 02 Malmö, SwedenNTNU Institute of Cancer Research and Molecular MedicineNorwegian University of Science and Technology, Trondheim University Hospital, Trondheim, NorwayDepartment of Public Health and Caring SciencesUppsala University, SE-751 22 Uppsala, SwedenDivision of EndocrinologyDepartment of Medicine, Helsinki University Central Hospital, Research Program for Diabetes and Obesity and Folkhalsan Research Center, University of Helsinki, F-00014 Helsinki, Finland.
Stockholm County Council · SELund University · SEUppsala University · SENorwegian University of Science and Technology · NOUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveModerate alcohol consumption is associated with a reduced risk of type 2 diabetes. Our aim was to investigate whether alcohol consumption is associated with the risk of latent autoimmune diabetes in adults (LADA), an autoimmune form of diabetes with features of type 2 diabetes.

designA population-based case-control study was carried out to investigate the association of alcohol consumption and the risk of LADA.

methodsWe used data from the ESTRID case-control study carried out between 2010 and 2013, including 250 incident cases of LADA (glutamic acid decarboxylase antibodies (GADAs) positive) and 764 cases of type 2 diabetes (GADA negative), and 1012 randomly selected controls aged ≥35. Logistic regression was used to estimate the odds ratios (ORs) of diabetes in relation to alcohol intake, adjusted for age, sex, BMI, family history of diabetes, smoking, and education.

resultsAlcohol consumption was inversely associated with the risk of type 2 diabetes (OR 0.95, 95% CI 0.92-0.99 for every 5-g increment in daily intake). Similar results were observed for LADA, but stratification by median GADA levels revealed that the results only pertained to LADA with low GADA levels (OR 0.85, 95% CI 0.76-0.94/5 g alcohol per day), whereas no association was observed with LADA having high GADA levels (OR 1.00, 95% CI 0.94-1.06/5 g per day). Every 5-g increment of daily alcohol intake was associated with a 10% increase in GADA levels (P=0.0312), and a 10% reduction in homeostasis model assessment of insulin resistance (P=0.0418).

conclusionsOur findings indicate that alcohol intake may reduce the risk of type 2 diabetes and type 2-like LADA, but has no beneficial effects on diabetes-related autoimmunity.

Indexed as

AdultAgedAlcohol DrinkingCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedRisk FactorsSurveys and QuestionnairesSweden

Identifiers

PMID25117461
PMCPMC4190680
OpenAlexW2115542244

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.