ArticlePloS one2014
Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Zoledronate Sequential Therapy After Denosumab Discontinuation to Prevent Bone Mineral Density Reduction: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Romosozumab increases bone mineral density in postmenopausal Chinese women with osteoporosis: A randomised phase three study.Journal of orthopaedic translation · 2026Article
- Personalizing denosumab therapy in postmenopausal Indian women with osteoporosis: predictive role of bone turnover markers and body mass index in determining dosing interval.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Observational
- Effects of vitamin DEndocrine · 2025Article
- Prediction model for low bone mass mineral density in type 2 diabetes: an observational cross-sectional study.Endocrine · 2024Observational
- The Use of Bone-Turnover Markers in Asia-Pacific Populations.Annals of laboratory medicine · 2024Review
- Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Review
- A Three-Year Follow-Up of Bone Density Among Thai Adolescents With Perinatally Acquired HIV After Completion of Vitamin D and Calcium Supplementation.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023Observational
- Clinical features and shared mechanisms of chronic gastritis and osteoporosis.Scientific reports · 2023Article
- The Imbalance of Cytokines and Lower Levels of Tregs in Elderly Male Primary Osteoporosis.Frontiers in endocrinology · 2022Article
- Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages.Frontiers in endocrinology · 2022Article
- Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Down-Regulated PI3K/AKT Signaling in Bone Tissues.Nature and science of sleep · 2022Article
- Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age.International journal of environmental research and public health · 2021Article
- Evaluation of bone metabolism-associated biomarkers in Tibet, China.Journal of clinical laboratory analysis · 2021Article
- Age-related changes and reference intervals of RANKL, OPG, and bone turnover markers in Indian women.Archives of osteoporosis · 2021Article
- Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair.Scientific reports · 2021Article
- Changes of bone turnover markers after elderly hip fracture surgery.Journal of bone and mineral metabolism · 2021Observational
- A Multi-Institutional Randomized Controlled Trial to Investigate Whether Zoledronate Prevents Bone Loss After Discontinuation of Denosumab: The Study Protocol of Denosumab Sequential Therapy (DST) Trial.Frontiers in medicine · 2021Article
- Ethnic, geographic, and seasonal differences of vitamin D status among adults in south-west China.Journal of clinical laboratory analysis · 2020Article
- Metabolomic Associations with Serum Bone Turnover Markers.Nutrients · 2020Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone formation marker procollagen I N-terminal peptide (PINP) and resorption marker C-terminal telopeptide of type I collagen (β-CTX) are useful biomarkers for differential diagnosis and therapeutic evaluation of osteoporosis, but reference values are required.
methodsThe multi-center, cross-sectional Chinese Bone Turnover Marker Study included 3800 healthy volunteers in 5 Chinese cities. Serum PINP, β-CTX, parathyroid hormone (PTH) and 25OHD levels were measured by chemiluminescence assay. Lumbar spine and proximal femur BMD were measured by dual-energy X-ray absorptiometry. Serum PINP and β-CTX levels were assessed by age, gender, weight, recruitment latitude, levels of PTH and 25OHD.
resultsSubjects (n = 1436, M:F, 500:936; mean age 50.6 ± 19.6 years) exhibited non-normally distributed PINP and β-CTX peaking between 15-19 years, gradually declining throughout adulthood, elevating within 10 years of postmenopause, and then declining by age 70. In women between the age of 30 and menopause, median PINP and β-CTX levels were 40.42 (95% CI: 17.10-102.15) and 0.26 (95% CI: 0.08-0.72) ng/mL, respectively. β-CTX and PINP were positively linearly correlated (r = 0.599, P<0.001). β-CTX correlated positively (r = 0.054 and 0.093) and PINP correlated negatively (r = -0.012 and -0.053) with 25OHD and PTH (P<0.05).
conclusionsWe established Chinese reference ranges for PINP and CTX. Chinese individuals exhibited high serum PINP and β-CTX levels between 15 and 19 years of age and at menopause, which gradually declined after 70 years of age.
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