ReviewCellular and molecular life sciences : CMLS2014
Evolution of nonclassical MHC-dependent invariant T cells.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Loss of Major Histocompatibility Complex I and II Function in the Genome of Glacier Lanternfish Provides Insight Into Evolution of Vertebrate Immune Systems.Genome biology and evolution · 2026Article
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Compact genomic architecture of the axolotl MHC region: setting the record straight.Immunogenetics · 2025Article
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- γδ T, NKT, and MAIT Cells During Evolution: Redundancy or Specialized Functions?Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018Review
- Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).PloS one · 2018Article
- Evolutionary Aspects of Macrophages Polarization.Results and problems in cell differentiation · 2017Review
- MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules?Immunogenetics · 2016Review
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- Double-negative T resident memory cells of the lung react to influenza virus infection via CD11c(hi) dendritic cells.Mucosal immunology · 2016Article
- Ouro proteins are not essential to tail regression during Xenopus tropicalis metamorphosis.Genes to cells : devoted to molecular & cellular mechanisms · 2016Article
- Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.Immunological reviews · 2015Review
- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.Immunological reviews · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
TCR-mediated specific recognition of antigenic peptides in the context of classical MHC molecules is a cornerstone of adaptive immunity of jawed vertebrate. Ancillary to these interactions, the T cell repertoire also includes unconventional T cells that recognize endogenous and/or exogenous antigens in a classical MHC-unrestricted manner. Among these, the mammalian nonclassical MHC class I-restricted invariant T cell (iT) subsets, such as iNKT and MAIT cells, are now believed to be integral to immune response initiation as well as in orchestrating subsequent adaptive immunity. Until recently the evolutionary origins of these cells were unknown. Here we review our current understanding of a nonclassical MHC class I-restricted iT cell population in the amphibian Xenopus laevis. Parallels with the mammalian iNKT and MAIT cells underline the crucial biological roles of these evolutionarily ancient immune subsets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.