ArticlePLoS biology2014
Adaptive evolution and environmental durability jointly structure phylodynamic patterns in avian influenza viruses.
Article in PLoS biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Evolutionary lineage and host origin influence virulence and mammalian adaptation of H7N9 avian influenza viruses.Poultry science · 2026Article
- Special Issue "Ecology of Influenza A Viruses": Editorial.Microorganisms · 2023Article
- Assessing the risk of human-to-wildlife pathogen transmission for conservation and public health.Ecology letters · 2022Review
- Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild reservoir species.PLoS pathogens · 2022Article
- Temporal dynamics and the influence of environmental variables on the prevalence of avian influenza virus in main wetlands in central Chile.Transboundary and emerging diseases · 2021Article
- Review
- A systemic approach to assess the potential and risks of wildlife culling for infectious disease control.Communications biology · 2020Review
- Dynamic and integrative approaches to understanding pathogen spillover.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Influenza Virus Segment Composition Influences Viral Stability in the Environment.Frontiers in microbiology · 2018Article
- Reconciling Pasteur and Darwin to control infectious diseases.PLoS biology · 2018Article
- Pleiotropic Effects of Resistance-Breaking Mutations on Particle Stability Provide Insight into Life History Evolution of a Plant RNA Virus.Journal of virology · 2017Article
- The ecology and adaptive evolution of influenza A interspecies transmission.Influenza and other respiratory viruses · 2017Review
- Antibody responses to avian influenza viruses in wild birds broaden with age.Proceedings. Biological sciences · 2016Article
- Does influenza A virus infection affect movement behaviour during stopover in its wild reservoir host?Royal Society open science · 2016Article
- Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data.The Journal of general virology · 2015Article
- Interdisciplinarity and Infectious Diseases: An Ebola Case Study.PLoS pathogens · 2015Article
- Avian influenza virus exhibits distinct evolutionary dynamics in wild birds and poultry.BMC evolutionary biology · 2015Article
- Adaptive evolution and environmental durability jointly structure phylodynamic patterns in avian influenza viruses.PLoS biology · 2014Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Avian influenza viruses (AIVs) have been pivotal to the origination of human pandemic strains. Despite their scientific and public health significance, however, there remains much to be understood about the ecology and evolution of AIVs in wild birds, where major pools of genetic diversity are generated and maintained. Here, we present comparative phylodynamic analyses of human and AIVs in North America, demonstrating (i) significantly higher standing genetic diversity and (ii) phylogenetic trees with a weaker signature of immune escape in AIVs than in human viruses. To explain these differences, we performed statistical analyses to quantify the relative contribution of several potential explanations. We found that HA genetic diversity in avian viruses is determined by a combination of factors, predominantly subtype-specific differences in host immune selective pressure and the ecology of transmission (in particular, the durability of subtypes in aquatic environments). Extending this analysis using a computational model demonstrated that virus durability may lead to long-term, indirect chains of transmission that, when coupled with a short host lifespan, can generate and maintain the observed high levels of genetic diversity. Further evidence in support of this novel finding was found by demonstrating an association between subtype-specific environmental durability and predicted phylogenetic signatures: genetic diversity, variation in phylogenetic tree branch lengths, and tree height. The conclusion that environmental transmission plays an important role in the evolutionary biology of avian influenza viruses-a manifestation of the "storage effect"-highlights the potentially unpredictable impact of wildlife reservoirs for future human pandemics and the need for improved understanding of the natural ecology of these viruses.
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