Evidence map›Paper›PMID 25116795›Full record

ArticleTranslational psychiatry2014

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

H M Chen, C J DeLong, M Bame, I Rajapakse, T J Herron, M G McInnis, K S O'Shea

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 6 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 6 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  3. Mental health dished up-the use of iPSC models in neuropsychiatric research.Journal of neural transmission (Vienna, Austria : 1996) · 2020
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  8. Microfluidic low-input profiling reveals lncRNA roles in disease.bioRxiv : the preprint server for biology · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

H M ChenDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.
C J DeLongDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
M BameDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.
I RajapakseCenter for Computational Medicine & Bioinformatics, Department of Mathematics, University of Michigan Medical School, Ann Arbor, MI, USA.
T J HerronDepartment of Cardiology, University of Michigan Medical School, Ann Arbor, MI, USA.
M G McInnisDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.
K S O'SheaDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder (BP) is a chronic psychiatric condition characterized by dynamic, pathological mood fluctuations from mania to depression. To date, a major challenge in studying human neuropsychiatric conditions such as BP has been limited access to viable central nervous system tissue to examine disease progression. Patient-derived induced pluripotent stem cells (iPSCs) now offer an opportunity to analyze the full compliment of neural tissues and the prospect of identifying novel disease mechanisms. We have examined changes in gene expression as iPSC derived from well-characterized patients differentiate into neurons; there was little difference in the transcriptome of iPSC, but BP neurons were significantly different than controls in their transcriptional profile. Expression of transcripts for membrane bound receptors and ion channels was significantly increased in BP-derived neurons compared with controls, and we found that lithium pretreatment of BP neurons significantly altered their calcium transient and wave amplitude. The expression of transcription factors involved in the specification of telencephalic neuronal identity was also altered. Control neurons expressed transcripts that confer dorsal telencephalic fate, whereas BP neurons expressed genes involved in the differentiation of ventral (medial ganglionic eminence) regions. Cells were responsive to dorsal/ventral patterning cues, as addition of the Hedgehog (ventral) pathway activator purmorphamine or a dorsalizing agent (lithium) stimulated expression of NKX2-1 (ventral identity) or EMX2 (dorsal) in both groups. Cell-based models should have a significant impact on our understanding of the genesis and therefore treatment of BP; the iPSC cell lines themselves provide an important resource for comparison with other neurodevelopmental disorders.

Indexed as

AdultBipolar DisorderBody PatterningCalcium SignalingCell DifferentiationDisease ProgressionEmpty Spiracles Homeobox ProteinsFemaleGene ExpressionHomeodomain ProteinsHumansLithium CarbonateLongitudinal StudiesMaleMiddle AgedNeuronsEmpty Spiracles Homeobox ProteinsHomeodomain ProteinsLithium CarbonateNuclear ProteinsThyroid Nuclear Factor 1Transcription Factors

Identifiers

PMID25116795
PMCPMC3966040
OpenAlexW2141263950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.