ArticleEndocrinology2014
Adipocyte versus pituitary leptin in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin.
Article in Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis.Lipids in health and disease · 2024Review
- Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.Cell metabolism · 2023Article
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle.Endocrinology · 2023Article
- Article
- Effects of the Seed Oil ofMolecules (Basel, Switzerland) · 2022Article
- The Effects of Nutrition on Linear Growth.Nutrients · 2022Review
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.Endocrinology · 2021Article
- The Importance of Leptin to Reproduction.Endocrinology · 2021Review
- Adiponectin, Leptin and Cardiovascular Disorders.Circulation research · 2021Review
- Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected withPathogens (Basel, Switzerland) · 2020Article
- Partial leptin deficiency confers resistance to diet-induced obesity in mice.Molecular metabolism · 2020Article
- Leptin: Less Is More.Diabetes · 2020Article
- Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.Cell metabolism · 2019Article
- Spilanthol from Traditionally UsedNutrients · 2019Article
- Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications.Endocrinology · 2018Article
- Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor.International journal of obesity (2005) · 2017Article
- The glucoregulatory actions of leptin.Molecular metabolism · 2017Review
- Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse.Journal of neuroendocrinology · 2017Article
- Adipokines (Leptin, Adiponectin, Resistin) Differentially Regulate All Hormonal Cell Types in Primary Anterior Pituitary Cell Cultures from Two Primate Species.Scientific reports · 2017Article
- A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones.Endocrinology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leptin is a cytokine produced by white fat cells, skeletal muscle, the placenta, and the pituitary gland among other tissues. Best known for its role in regulating appetite and energy expenditure, leptin is produced largely by and in proportion to white fat cells. Leptin is also important to the maintenance and function of the GH cells of the pituitary. This was shown when the deletion of leptin receptors on somatotropes caused decreased numbers of GH cells, decreased circulating GH, and adult-onset obesity. To determine the source of leptin most vital to GH cells and other pituitary cell types, we compared two different leptin knockout models with Cre-lox technology. The global Lep-null model is like the ob/ob mouse, whereby only the entire exon 3 is deleted. The selective adipocyte-Lep-null model lacks adipocyte leptin but retains pituitary leptin, allowing us to investigate the pituitary as a potential source of circulating leptin. Male and female mice lacking adipocyte leptin (Adipocyte-lep-null) did not produce any detectable circulating leptin and were infertile, suggesting that the pituitary does not contribute to serum levels. In the presence of only pituitary leptin, however, these same mutants were able to maintain somatotrope numbers and GH mRNA levels. Serum GH trended low, but values were not significant. However, hypothalamic GHRH mRNA was significantly reduced in these animals. Other serum hormone and pituitary mRNA differences were observed, some of which varied from previous results reported in ob/ob animals. Whereas pituitary leptin is capable of maintaining somatotrope numbers and GH mRNA production, the decreased hypothalamic GHRH mRNA and low (but not significant) serum GH levels indicate an important role for adipocyte leptin in the regulation of GH secretion in the mouse. Thus, normal GH secretion may require the coordinated actions of both adipocyte and pituitary leptin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.