Evidence map›Paper›PMID 25115692›Full record

ArticleClinical and experimental pharmacology & physiology2014

Recent progress in gastric arrhythmia: pathophysiology, clinical significance and future horizons.

Gregory O'Grady, Tim H-H Wang, Peng Du, Tim Angeli, Wim J E P Lammers, Leo K Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental pharmacology & physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021
    Pooled it
  5. Trial
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  7. Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026
    Article
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  11. Review
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  13. [A New Paradigm in Diagnosing Functional Gastroduodenal Disorders: High-Resolution Electrogastrography].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Gregory O'GradyDepartment of Surgery, The University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Tim H-H Wang
Peng Du
Tim Angeli
Wim J E P Lammers
Leo K Cheng
University of Auckland · NZVanderbilt University · US

Funding

Realistic models of gastrointestinal bioelectromagnetismR01DK064775 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHENG, LEO · 2004 to 2014
$2.6M
NIDDK NIH HHS R01 DK064775NIDDK NIH HHS R01 DK64775
6 · The paper itself

Abstract

Gastric arrhythmia continues to be of uncertain diagnostic and therapeutic significance. However, recent progress has been substantial, with technical advances, theoretical insights and experimental discoveries offering new translational opportunities. The discoveries that interstitial cells of Cajal (ICC) generate slow waves and that ICC defects are associated with dysmotility have reinvigorated gastric arrhythmia research. Increasing evidence now suggests that ICC depletion and damage, network disruption and channelopathies may lead to aberrant slow wave initiation and conduction. Histological and high-resolution (HR) electrical mapping studies have now redefined the human 'gastric conduction system', providing an improved baseline for arrhythmia research. The application of HR mapping to arrhythmia has also generated important new insights into the spatiotemporal dynamics of arrhythmia onset and maintenance, resulting in the emergence of new provisional classification schemes. Meanwhile, the strong associations between gastric functional disorders and electrogastrography (EGG) abnormalities (e.g. in gastroparesis, unexplained nausea and vomiting and functional dyspepsia) continue to motivate deeper inquiries into the nature and causes of gastrointestinal arrhythmias. In future, technical progress in EGG methods, new HR mapping devices and software, wireless slow wave acquisition systems and improved gastric pacing devices may achieve validated applications in clinical practice. Neurohormonal factors in arrhythmogenesis also continue to be elucidated and a deepening understanding of these mechanisms may open opportunities for drug design for treating arrhythmias. However, for all translational goals, it remains to be seen whether arrhythmia can be corrected in a way that meaningfully improves organ function and symptoms in patients.

Indexed as

DyspepsiaGastrointestinal MotilityGastroparesisHumansInterstitial Cells of CajalNauseaSoftwareStomachVomitingelectrogastrographygastric electrical activityhigh-resolution mappinginterstitial cells of Cajaltachygastria

Identifiers

PMID25115692
PMCPMC4359928
OpenAlexW1991345660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.