ArticlePloS one2014
Acute respiratory failure in critically ill patients with interstitial lung disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Risk factors for mortality and mortality rates in interstitial lung disease patients in the intensive care unit.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Chronic lung diseases and kidney disease: pathophysiology and management.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Impact of oxygenation strategies on outcome in acute exacerbation of interstitial lung disease.ERJ open research · 2025Article
- Diagnostic approach in acute hypoxemic respiratory failure.Journal of intensive medicine · 2025Review
- Diagnosis and management of autoimmune diseases in the ICU.Intensive care medicine · 2024Review
- The Antifibrotic Effects of Inhaled Treprostinil: An Emerging Option for ILD.Advances in therapy · 2022Review
- ERS International Congress 2020 Virtual: highlights from the Respiratory Intensive Care Assembly.ERJ open research · 2021Article
- Interstitial Lung Disease Worsens Short- and Long-Term Outcomes of Systemic Rheumatic Disease Patients Admitted to the ICU: A Multicenter Study.Journal of clinical medicine · 2021Article
- A population-based observational study of patients with pulmonary disorders in intensive care unit.The Korean journal of internal medicine · 2020Observational
- Ventilatory support and mechanical properties of the fibrotic lung acting as a "squishy ball".Annals of intensive care · 2020Review
- Interstitial Lung Disease Associated Acute Respiratory Failure Requiring Invasive Mechanical Ventilation: A Retrospective Analysis.The open respiratory medicine journal · 2020Article
- Prognostic effects of clinical and CT imaging features on critically ill patients with interstitial lung disease hospitalized in respiratory intensive care unit.Scientific reports · 2019Article
- Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study.Annals of intensive care · 2018Article
- Acute respiratory failure due to diffuse parenchymal lung diseases in a respiratory intensive care unit of North India.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?Annals of intensive care · 2017Article
- Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.Intensive care medicine · 2016Article
- Outcome and prognostic factors of interstitial lung disease patients with acute respiratory failure in the intensive care unit.Therapeutic advances in respiratory diseaseObservational
- Unmet Needs for Palliation in Fibrotic Interstitial Lung Disease.Indian journal of palliative careArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with chronic known or unknown interstitial lung disease (ILD) may present with severe respiratory flares that require intensive management. Outcome data in these patients are scarce. PATIENTS AND
methodsClinical and radiological features were collected in 83 patients with ILD-associated acute respiratory failure (ARF). Determinants of hospital mortality and response to corticosteroid therapy were identified by logistic regression.
resultsHospital and 1-year mortality rates were 41% and 54% respectively. Pulmonary hypertension, computed tomography (CT) fibrosis and acute kidney injury were independently associated with mortality (odds ratio (OR) 4.55; 95% confidence interval (95%CI) (1.20-17.33); OR, 7.68; (1.78-33.22) and OR 10.60; (2.25-49.97) respectively). Response to steroids was higher in patients with shorter time from hospital admission to corticosteroid therapy. Patients with fibrosis on CT had lower response to steroids (OR, 0.03; (0.005-0.21)). In mechanically ventilated patients, overdistension induced by high PEEP settings was associated with CT fibrosis and hospital mortality.
conclusionMortality is high in ILD-associated ARF. CT and echocardiography are valuable prognostic tools. Prompt corticosteroid therapy may improve survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.