ArticleEpidemiology and infection2015
Cross-immunity and age patterns of influenza A(H5N1) infection.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Age-specific mortality patterns across influenza pandemics: evidence from all-cause mortality data across multiple populations.International journal of epidemiology · 2026Article
- Article
- Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Seasonality in risk of pandemic influenza emergence.PLoS computational biology · 2017Article
- Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting.Science (New York, N.Y.) · 2016Article
- Relevance of workplace social mixing during influenza pandemics: an experimental modelling study of workplace cultures.Epidemiology and infection · 2016Article
- The pandemic potential of avian influenza A(H7N9) virus: a review.Epidemiology and infection · 2015Review
- Characterizing the transmission potential of zoonotic infections from minor outbreaks.PLoS computational biology · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The age distribution of influenza A(H5N1) cases reported during 2006-2013 varied substantially between countries. As well as underlying demographic profiles, it is possible that cross-immunity contributed to the age distribution of reported cases: seasonal influenza A(H1N1) and avian influenza A(H5N1) share the same neuraminidase subtype, N1. Using a mechanistic model, we measured the extent to which population age distribution and heterosubtypic cross-immunity could explain the observed age patterns in Cambodia, China, Egypt, Indonesia and Vietnam. Our results support experimental evidence that prior infection with H1N1 confers partial cross-immunity to H5N1, and suggest that more than 50% of spillover events did not lead to reported cases of infection as a result. We also identified age groups that have additional risk factors for influenza A(H5N1) not captured by demography or infection history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.