ArticleEuropean journal of nutrition2015
Short- and long-term effects of a maternal low-energy diet ad libitum during gestation and/or lactation on physiological parameters of mothers and male offspring.
Article in European journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Litter sex composition influences plasma prolactin levels but not the melanin-concentrating hormone immunoreactive neurons in the medial preoptic area of late lactating Long-Evans rats.Journal of neuroendocrinology · 2025Article
- Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative Changes.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Effects of maternal dietary energy restriction on laying performance, embryonic development, and lipid metabolism in broilers.Animal bioscience · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the short- and long-term effects of a maternal low-energy diet ad libitum during gestation and/or lactation on mothers and their offspring.
methodsMale Wistar rats were divided into four groups according to their mother's diet: control [C (19.0% protein, 63.0% carbohydrates and 18.0% lipids, total energetic value (TEV) = 3.5 kcal/g) during gestation and lactation], low-energy diet (18% protein, 64% carbohydrates and 18% lipids, TEV = 2.3 kcal/g) during gestation (LE-G), low-energy diet during lactation (LE-L) and low-energy diet during gestation and lactation (LE-GL). Additional crude fibers (10% more purified cellulose and soluble fiber) and water (approximately 30% greater moisture) were added to the LE diet to decrease TEV. Mother's body weight, food intake and energy intake were recorded daily. Birth weight, growth rate, ontogeny of reflexes, physical features and biochemical parameters at 150 days old were evaluated in male offspring.
resultsMaternal low-energy diet during gestation did not affect maternal body weight and food intake. Physical features did not change but reflex ontogeny was delayed in pups from LE dams. LE-G offspring recovered body size (weight and length) while animals LE-L and LE-GL recovered their body length but remained lighter until adult life even with no change of food intake. LE-G and LE-GL showed lower plasma triglycerides and very-low-density-lipoprotein cholesterol (VLDL). LE-L offspring showed hypertriglyceridemia, high VLDL-c and reduced glycaemia.
conclusionMaternal low-energy diet shows discernible short- and long-term effects on offspring, and this is dependent on the time of perinatal period.
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