Evidence map›Paper›PMID 25115135›Full record

ArticleJournal of substance abuse treatment2015

Denial of urinalysis-confirmed opioid use in prescription opioid dependence.

E Yvette Hilario, Margaret L Griffin, R Kathryn McHugh, Katherine A McDermott, Hilary S Connery, Garrett M Fitzmaurice, Roger D Weiss

Abstract read
In one paragraph

Article in Journal of substance abuse treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Applying Artificial Intelligence to Expand the Measurement Tool Kit in Clinical-Psychological Science: Moving Beyond Self-Reports.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Methods to reduce false reporting of substance abstinence in clinical research.International journal of methods in psychiatric research · 2018
    Article
  10. Article
  11. Article
  12. Prescription drug abuse: from epidemiology to public policy.Journal of substance abuse treatment · 2015
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

E Yvette HilarioDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA.
Margaret L GriffinDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
R Kathryn McHughDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
Katherine A McDermottDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA.
Hilary S ConneryDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
Garrett M FitzmauriceDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric Biostatistics, McLean Hospital, Belmont, MA 02478, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Roger D WeissDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rweiss@mclean.harvard.edu.

Funding

The National Drug Abuse Treatment Clinical Trials Network (U10)U10DA015831 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI CARROLL, KATHLEEN M., WEISS, ROGER D. · 2002 to 2015
$28.8M
Mentoring in Drug Abuse and Dual Diagnosis ResearchK24DA022288 · NIDA · MCLEAN HOSPITAL · PI WEISS, ROGER D. · 2007 to 2016
$1.8M
NIDA NIH HHS K24 DA022288NIDA NIH HHS K24DA022288NIDA NIH HHS U10 DA015831NIDA NIH HHS U10DA015831
6 · The paper itself

Abstract

Although research has generally supported the validity of substance use self-reports, some patients deny urine-verified substance use. We examined the prevalence and patterns of denying urinalysis-confirmed opioid use in a sample of prescription opioid dependent patients. We also identified characteristics associated with denial in this population of increasing public health concern. Opioid use self-reports were compared with weekly urinalysis results in a 12-week multi-site treatment study for prescription opioid dependence. Among those who used opioids during the trial (n=246/360), 44.3% (n=109) denied urinalysis-confirmed opioid use, although usually only once (78%). Overall, 22.9% of opioid-positive urine tests (149/650) were denied on self-report. Multivariable analysis found that initially using opioids to relieve pain was associated with denying opioid use. These findings support the use of both self-reports and urine testing in treating prescription opioid dependence.

Indexed as

Self ReportAdultClinical Trials as TopicFemaleHumansMaleMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPrescription Drug MisuseUrinalysisAddictionOpioidsOpioid use disorderPainPrescription opioid dependenceSelf-reportSubstance use disorderUrine screens

Identifiers

PMID25115135
PMCPMC4250346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.