ArticleGenome biology and evolution2014
The molecular evolution of the Qo motif.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Flexibility and Hydration of the QJournal of chemical information and modeling · 2025Article
- Inhibition mechanism of potential antituberculosis compound lansoprazole sulfide.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Long-range charge transfer mechanism of the IIINature communications · 2024Article
- Structure and function of theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- High-resolution cryo-EM structures of plant cytochrome bScience advances · 2023Article
- Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy.Biochemical Society transactions · 2022Review
- Structural basis for safe and efficient energy conversion in a respiratory supercomplex.Nature communications · 2022Article
- Structure and Mechanism of Respiratory III-IV Supercomplexes in Bioenergetic Membranes.Chemical reviews · 2021Review
- Architecture of bacterial respiratory chains.Nature reviews. Microbiology · 2021Review
- Catalytic Reactions and Energy Conservation in the CytochromeChemical reviews · 2021Review
- Decoding the Molecular Effects of Atovaquone Linked Resistant Mutations onInternational journal of molecular sciences · 2021Article
- Article
- Structure-function of the cytochrome bPhotosynthesis research · 2019Review
- Resource Concentration Modulates the Fate of Dissimilated Nitrogen in a Dual-Pathway Actinobacterium.Frontiers in microbiology · 2019Article
- On the Natural History of Flavin-Based Electron Bifurcation.Frontiers in microbiology · 2018Review
- Emergence of cytochrome bc complexes in the context of photosynthesis.Physiologia plantarum · 2017Article
- The cytochrome b Zn binding amino acid residue histidine 291 is essential for ubihydroquinone oxidation at the QBiochimica et biophysica acta · 2016Article
- Dysregulated mitochondrial and chloroplast bioenergetics from a translational medical perspective (Review).International journal of molecular medicine · 2016Review
- Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching.Medical science monitor : international medical journal of experimental and clinical research · 2015Review
- Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.Antimicrobial agents and chemotherapy · 2015Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Quinol oxidation in the catalytic quinol oxidation site (Q(o) site) of cytochrome (cyt) bc(1) complexes is the key step of the Q cycle mechanism, which laid the ground for Mitchell's chemiosmotic theory of energy conversion. Bifurcated electron transfer upon quinol oxidation enables proton uptake and release on opposite membrane sides, thus generating a proton gradient that fuels ATP synthesis in cellular respiration and photosynthesis. The Q(o) site architecture formed by cyt b and Rieske iron-sulfur protein (ISP) impedes harmful bypass reactions. Catalytic importance is assigned to four residues of cyt b formerly described as PEWY motif in the context of mitochondrial complexes, which we now denominate Q(o) motif as comprehensive evolutionary sequence analysis of cyt b shows substantial natural variance of the motif with phylogenetically specific patterns. In particular, the Q(o) motif is identified as PEWY in mitochondria, α- and ε-Proteobacteria, Aquificae, Chlorobi, Cyanobacteria, and chloroplasts. PDWY is present in Gram-positive bacteria, Deinococcus-Thermus and haloarchaea, and PVWY in β- and γ-Proteobacteria. PPWF only exists in Archaea. Distinct patterns for acidophilic organisms indicate environment-specific adaptations. Importantly, the presence of PDWY and PEWY is correlated with the redox potential of Rieske ISP and quinone species. We propose that during evolution from low to high potential electron-transfer systems in the emerging oxygenic atmosphere, cyt bc(1) complexes with PEWY as Q(o) motif prevailed to efficiently use high potential ubiquinone as substrate, whereas cyt b with PDWY operate best with low potential Rieske ISP and menaquinone, with the latter being the likely composition of the ancestral cyt bc(1) complex.
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