ArticleBioMed research international2014
Antidiabetic effect of Sida cordata in alloxan induced diabetic rats.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Hyperglycemia associated brain dysfunction: rodent models for studying diabetic cognitive deficits.Metabolic brain disease · 2026Review
- Antidiabetic Potential of Sea UrchinCurrent issues in molecular biology · 2025Article
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- Phytochemical Screening and Antidiabetic Potential ofFood science & nutrition · 2025Article
- In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions.Scientific reports · 2024Article
- Vulgarin, a Sesquiterpene Lactone fromInternational journal of molecular sciences · 2022Article
- Anti-Diabetic Effects ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Hyperglycemia-associated Alzheimer's-like symptoms and other behavioral effects attenuated byFrontiers in pharmacology · 2022Article
- Phytochemicals of Periploca aphylla Dcne. ameliorated streptozotocin-induced diabetes in rat.Environmental health and preventive medicine · 2021Article
- Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Effect of olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Molecular and biochemical monitoring of the possible herb-drug interaction betweenSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Article
- Antidiabetic Activity ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts.Pharmaceutical biology · 2017Article
- Impact ofJournal of pharmacopuncture · 2017Article
- Protective effects of Fraxinus xanthoxyloides (Wall.) leaves against CClBMC complementary and alternative medicine · 2016Article
- Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations.Journal of traditional and complementary medicine · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medicinal plants are efficient ameliorator of oxidative stress associated with diabetes mellitus. In this study, ethyl acetate fraction (SCEE) of Sida cordata was investigated for scientific validation of its folk use in diabetes. Antidiabetic effect of SCEE was confirmed by antihyperglycemic activity in normal glucose loaded and diabetic glucose loaded animals as well as normal off feed animals. Confirmation of antidiabetic activity and toxicity ameliorative role of S. cordata was investigated in a chronic multiple dose treatment study of fifteen days. A single dose of alloxan (120 mg/kg) produced a decrease in insulin level, hyperglycemia, elevated total lipids, triglycerides, and cholesterol and decreased the high-density lipoproteins. Concurrent with these changes, there was an increase in the concentration of lipid peroxidation (TBARS), H2O2, and nitrite in pancreas, liver, and testis. This oxidative stress was related to a decrease in glutathione content (GSH) and antioxidant enzymes. Administration of SCEE for 15 days after diabetes induction ameliorated hyperglycemia, restored lipid profile, blunted the increase in TBARS, H2O2, and nitrite content, and stimulated the GSH production in the organs of alloxan-treated rats. We suggested that SCEE could be used as antidiabetic component in case of diabetes mellitus. This may be related to its antioxidative properties.
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