Trial reportBioMed research international2014
Modulation of circulating macrophage migration inhibitory factor in the elderly.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Bridging aging, immunity, and atherosclerosis: novel insights into senescence-related genes.Frontiers in immunology · 2025Article
- Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoEFrontiers in pharmacology · 2025Article
- Strategies for arterial graft optimization at the single-cell level.Nature cardiovascular research · 2024Article
- Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice.Physiological reports · 2023Article
- The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression.Frontiers in immunology · 2023Article
- Comparative Study of Human and Murine Aortic Biomechanics and Hemodynamics in Vascular Aging.Frontiers in physiology · 2021Article
- Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly.Pharmacology & therapeutics · 2019Review
- Article
- Myocardial Expression of Macrophage Migration Inhibitory Factor in Patients with Heart Failure.Journal of clinical medicine · 2017Article
- Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate.Oxidative medicine and cellular longevity · 2017Review
- Article
- Renal replacement therapy neutralizes elevated MIF levels in septic shock.Journal of intensive care · 2016Article
- Potential of dietary nitrate in angiogenesis.World journal of cardiology · 2015Review
- Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.American journal of physiology. Cell physiology · 2015Article
- Dietary nitrate is a modifier of vascular gene expression in old male mice.Oxidative medicine and cellular longevity · 2015Article
- Filtration of Macrophage Migration Inhibitory Factor (MIF) in Patients with End Stage Renal Disease Undergoing Hemodialysis.PloS one · 2015Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.