ReviewBioMed research international2014
Heavy silicone oil and intraocular inflammation.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Heavy and standard silicone oil: intraocular inflammation.International ophthalmology · 2018Pooled it
- The anti-inflammatory effects of dexamethasone implants in eyes with heavy silicone oil: a prospective study on vitrectomy for diabetic retinopathy.Frontiers in endocrinology · 2025Trial
- Silicone oil tamponade in vitreoretinal surgery and future perspective: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Viscosity matters: OCTA assessment of retinal microcirculation under silicone oil tamponade.International ophthalmology · 2026Observational
- Toxic posterior segment syndrome induced by silicone oil tamponade after surgery for rhegmatogenous retinal detachment: a case report.BMC ophthalmology · 2026Article
- Vitreous Substitutes in Vitreoretinal Surgery: From Native Vitreous Physiology to Bioengineered Experimental Replacements.Journal of functional biomaterials · 2026Review
- Next-generation smart ophthalmic biomaterials: From passive response to active interaction and closed-loop control.Bioactive materials · 2026Review
- Emulsification Complexity of Silicone Oil in Retinal Surgery: In Vitro Insights into Phase Behavior.ACS omega · 2026Article
- Article
- Review
- Varicella Zoster Virus-Induced Retinitis and Retinal Detachment in an Immunocompetent Patient: A Case Report.The American journal of case reports · 2025Article
- An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy.BMC ophthalmology · 2025Article
- Combined anterior corneal elastic sublaminectomy, conjunctival flap, and prosthetic eyepiece for ocular atrophy following foldable capsular vitreous body implantation in severe trauma.International journal of ophthalmology · 2025Article
- The Role of Eye Movements in the Process of Silicone Oil Emulsification After Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2024Article
- Retrospective case series of high-density silicone oil (Oxane HD) in severe proliferative vitreorretinal retinal detachment patients.International journal of retina and vitreous · 2024Article
- Unexplained visual loss in retinal detachment repair: comparing gas, silicone oil and heavy silicone oil by multivariable regression.International journal of retina and vitreous · 2023Article
- Retinal Nerve Fiber Layer Changes after Intraocular Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment.Vision (Basel, Switzerland) · 2023Article
- Advances in Polysaccharide- and Synthetic Polymer-Based Vitreous Substitutes.Pharmaceutics · 2023Review
- Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery.International journal of molecular sciences · 2023Review
- Main Principles of Vitrectomy Using Intraocular Tamponades - A Basic Course in Surgery.Klinische Monatsblatter fur Augenheilkunde · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past two decades, many advances have been made in vitrectomy instrumentation, surgical techniques, and the use of different tamponade agents. These agents serve close retinal breaks, confine eventual retinal redetachment, and prevent proliferative vitreoretinopathy (PVR). Long-acting gases and silicone oil are effective internal tamponade agents; however, because their specific gravity is lower than that of the vitreous fluid, they may provide adequate support for the superior retina but lack efficacy for the inferior retina, especially when the fill is subtotal. Thus, a specific role may exist for an internal tamponade agent with a higher specific gravity, such as heavy silicone oils (HSOs), Densiron 68, Oxane HD, HWS 45-300, HWS 46-3000, and HeavySil. Some clinical evidence seems to presume that heavy tamponades are more prone to intraocular inflammation than standard silicone if they remain in the eye for several months. In this review, we discuss the fundamental clinical and biochemical/molecular mechanisms involved in the inflammatory response after the use of heavy tamponade: toxicity due to impurities or instability of the agent, direct toxicity and immunogenicity, oil emulsification, and mechanical injury due to gravity. The physical and chemical properties of various HSOs and their efficacy and safety profiles are also described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.