ArticleCMAJ open2014
Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study.
Article in CMAJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Increasing Cervical Cancer Rates Among Women Age 35-54 Years in Canada: Age-Specific Cervical Cancer Incidence Trends in Canada, 1992-2022.JCO oncology advances · 2025Article
- Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990-2015).Journal of clinical medicine · 2023Article
- Epidemiology of human papillomavirus-associated anogenital cancers in Granada: a three-decade population-based study.Frontiers in public health · 2023Observational
- Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada.Current oncology (Toronto, Ont.) · 2020Article
- The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review.Systematic reviews · 2020Article
- The emerging risk of oropharyngeal and oral cavity cancer in HPV-related subsites in young people in Brazil.PloS one · 2020Article
- Cancer burden attributable to human papillomavirus infection by sex, cancer site, age, and geographical area in China.Cancer medicine · 2020Article
- Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review.BMC cancer · 2019Article
- Human papillomavirus in oropharyngeal cancer in Canada: analysis of 5 comprehensive cancer centres using multiple imputation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- Management delays in patients with squamous cell cancer of neck node(s) and unknown primary site: a retrospective cohort study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2017Article
- Transoral laser microsurgery for the treatment of oropharyngeal cancer: the Dalhousie University experience.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015Article
- Oral health and prevention and screening for HPV.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecent epidemiologic studies have suggested that the incidence of noncervical cancers associated with human papillomavirus (HPV) is increasing. We assessed temporal, age-specific and sex-specific changes in the incidence of HPV-associated cancers in a population-based study.
methodsWe used the Alberta Cancer Registry, a registry of all cancers diagnosed in the province of Alberta, Canada, to identify patients with cancers of the oropharynx, cervix, vulva, vagina, anus and penis (cancers associated with HPV) between Jan. 1, 1975, and Dec. 31, 2009. We estimated the age-standardized incidence of each cancer by sex- and age-specific group and assessed the annual percentage change using joinpoint regression.
resultsThe age-standardized incidence of oropharyngeal cancers increased for each 5-year interval of the study period among men (annual percentage change 3.4, p < 0.001) and women (annual percentage change 1.5, p = 0.009). For anal cancers, the age-standardized rates increased among women (annual percentage change 2.2, p < 0.001) and men (annual percentage change 1.8, p = 0.008). The age-standardized incidence of cervical cancer increased with age, reaching an annual percentage change of -3.5 among women aged 75-84 years (p = 0.04). The rates of other HPV-associated cancers (vulvar, vaginal and penile) showed little change.
interpretationOur findings showed increases in the incidence of the HPV-associated cancers of the oropharynx and anus among men and women, and increases in cervical cancer among younger women. The incidence of HPV-related cancers in younger age groups should continue to be monitored. Programs to prevent HPV infection, such as vaccination, should be considered for males as well as females.
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