Evidence map›Paper›PMID 25114871›Full record

ArticleEuropean thyroid journal2014

2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children.

John Lazarus, Rosalind S Brown, Chantal Daumerie, Alicja Hubalewska-Dydejczyk, Roberto Negro, Bijay Vaidya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European thyroid journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 266 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
266citing papers in PubMed, 20 pooled it
38.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

266 citing papers in PubMed, 20 syntheses or guidelines pooled it, 724 citations in OpenAlex.

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  7. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2024
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  19. Atencion primaria · 2018
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206 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

John LazarusThyroid Research Group, Institute of Molecular Medicine, Cardiff University, University Hospital of Wales, Cardiff, Exeter, UK.
Rosalind S BrownClinical Trials Research Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Mass., USA.
Chantal DaumerieEndocrinologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Alicja Hubalewska-DydejczykDepartment of Endocrinology, Jagiellonian University Medical College, Krakow, Poland.
Roberto NegroDivision of Endocrinology, V. Fazzi Hospital, Lecce, Italy.
Bijay VaidyaDepartment of Endocrinology, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, UK.
Jagiellonian University · PLOspedale Vito Fazzi · ITUniversity of Exeter · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above the pregnancy-related reference range with a normal serum thyroxine concentration. Isolated hypothyroxinaemia (defined as a thyroxine level below the 2.5th centile of the pregnancy-related reference range with a normal TSH level) is also recognized in pregnancy. In the majority of SCH the cause is autoimmune thyroiditis but may also be due to iodine deficiency. The cause of isolated hypothyroxinaemia is usually not apparent, but iodine deficiency may be a factor. SCH and isolated hypothyroxinaemia are both associated with adverse obstetric outcomes. Levothyroxine therapy may ameliorate some of these with SCH but not in isolated hypothyroxinaemia. SCH and isolated hypothyroxinaemia are both associated with neuro-intellectual impairment of the child, but there is no evidence that maternal levothyroxine therapy improves this outcome. Targeted antenatal screening for thyroid function will miss a substantial percentage of women with thyroid dysfunction. In children SCH (serum TSH concentration >5.5-10 mU/l) normalizes in >70% and persists in the majority of the remaining patients over the subsequent 5 years, but rarely worsens. There is a lack of studies examining the impact of SCH on the neuropsychological development of children under the age of 3 years. In older children, the evidence for an association between SCH and impaired neuropsychological development is inconsistent. Good quality studies examining the effect of treatment of SCH in children are lacking.

Indexed as

ChildHypothyroidismIodineManagementPregnancyScreeningSubclinical

Identifiers

PMID25114871
PMCPMC4109520
OpenAlexW2140494520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.