ArticleTherapeutic advances in drug safety2013
Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports.
Article in Therapeutic advances in drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication.Frontiers in medicine · 2022Pooled it
- Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.Psychopharmacology · 2013Pooled it
- Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases.International journal of molecular sciences · 2023Review
- The modifying effect of the serum-to-dialysate potassium gradient on the cardiovascular safety of SSRIs in the hemodialysis population: a pharmacoepidemiologic study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Article
- Effects of antidepressants on QT interval in people with mental disorders.Archives of medical science : AMS · 2020Review
- QT interval prolongation andTherapeutic advances in drug safety · 2020Article
- Lack of relationship between plasma levels of escitalopram and QTc-interval length.European archives of psychiatry and clinical neuroscience · 2017Article
- Prevalence and correlates of QTc prolongation in Italian psychiatric care: cross-sectional multicentre study.Epidemiology and psychiatric sciences · 2016Article
- Selective serotonin reuptake inhibitors and cardiovascular events: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning.Balkan medical journal · 2015Article
- Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity.Therapeutic advances in infectious disease · 2014Article
- Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy.Case reports in cardiology · 2014Article
- Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports.Therapeutic advances in infectious disease · 2013Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the light of the recent United States Food and Drug Administration (FDA) warning to clinicians on using previously approved doses of citalopram because of the purported higher risk of torsade de pointes (TdP), we pursued the broader question: are selective serotonin reuptake inhibitor (SSRI) antidepressant agents as a group unsafe because they might induce QTc interval prolongation and TdP?
methodWe reviewed the literature and found only 15 case reports (6 of fluoxetine, 1 of sertraline and 8 of citalopram) of SSRI-associated QTc interval prolongation linking to TdP.
resultsA total of 13 cases contained sufficient information for analysis. In the setting of TdP, QTc interval prolongation does not clearly relate to SSRI dose.
conclusionApplying conventional statistics as the FDA does may not be the best tool to study this phenomenon because SSRI-associated TdP is a very rare event and hence best understood as an 'extreme outlier'. Despite the limitations inherent in case report material, case reports on drug-associated QTc interval prolongation and TdP provide valuable information that should be considered along with other sources of information for clinical guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.