ArticleIranian journal of reproductive medicine2014
Evaluating the effects of Escanbil (Calligonum) extract on the expression level of Catsper gene variants and sperm motility in aging male mice.
Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Antioxidant Effects of Brown Algae Sargassum on Sperm Parameters: CONSORT-Compliant Article.Medicine · 2015Trial
- Quercetin modulates transcription of the apoptotic and CatSper genes and optimises post thaw viability and kinematics of buck spermatozoa.Scientific reports · 2025Article
- Calcium Channels and Modulators as Potential Therapeutic Targets for Contraceptives and Male Fertility: A Scoping Review.Open access journal of contraception · 2025Review
- The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review.Current issues in molecular biology · 2023Review
- Testicular aging, male fertility and beyond.Frontiers in endocrinology · 2022Review
- Potent antioxidant and anticancer activities of the methanolic extract ofSaudi journal of biological sciences · 2021Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
- Antioxidant effects of calligonum extract on ovarian tissue of PCO model: An experimental study.International journal of reproductive biomedicine · 2018Article
- Alteration inInternational journal of reproductive biomedicine · 2018Article
- An Experimental Study of the Effects of Combined Exposure to Microwave and Heat on Gene Expression and Sperm Parameters in Mice.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCatsper proteins are responsible for entering Ca(2+) to the cell and play an important role in sperm motility and male fertility. Antioxidants are vital for sperm motility too. Escanbil (Calligonum) extract possess some of the important antioxidant like Catechin and Quercetin.
objectiveHere we investigated the effects of Escanbil (Calligonum) extract on the sperm parameters and the expressing of Catsper gene in aging male mice. MATERIALS AND
methodsIn this animal study, firstly, dose response was performed by using these three doses of Escanbil (Calligonum) (10, 30 and 50 mg/kg). 5 mice in each group were considered and Intra Peritoneal injection was done for 5 weeks. the sperm parameters analyzed and dUTP nick end labeling (TUNEL )staining was done. 30 mg/kg dose was considered as optimum dose. Secondly: fifteen aging male mice (11-13 months) were divided into three groups: control, sham and experiment. The experiments were injected Intra peritonealy with Escanbil (Calligonum) extract (30mg/kg) weekly for up to 5 weeks. The sham group was injected Intra Peritoneal (DMSO). Sperm parameters were analyzed. Expression of Catsper genes was analyzed by Real time PCR.
resultsOur results showed that after Escanbil (Calligonum) treatment (30 mg/kg), the sperm parameters were improved in experimental group (p<0.05). Our data showed that there was a statistical significance difference between the expressions of Catsper 2, 4 in aging experiment group comparison with aging control group (p<0.05).
conclusionWe investigated that the Escanbil (Calligonum) extract (30 mg/kg) can improve sperm parameters and change the expression of Catsper genes in aging male mice. This herbal extract can be used as an antioxidant component for clinical usages.
Indexed as
Identifiers
25114667PMC4126249W2177924481What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.