Evidence map›Paper›PMID 25114581›Full record

ArticlePharmacogenomics and personalized medicine2014

CYP19A1 single nucleotide polymorphism associations with CYP19A1, NFκB1, and IL6 gene expression in human normal colon and normal liver samples.

Rosalind B Penney, Abbie Lundgreen, Aiwei Yao-Borengasser, Vineetha K Edavana, Suzanne Williams, Ishwori Dhakal, Roger K Wolff, Susan Kadlubar, Martha L Slattery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rosalind B PenneyDepartment of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Abbie LundgreenDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Aiwei Yao-BorengasserDivision of Medical Genetics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vineetha K EdavanaDivision of Medical Genetics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Suzanne WilliamsDivision of Medical Genetics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ishwori DhakalDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Roger K WolffDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Susan KadlubarDivision of Medical Genetics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
University of Arkansas for Medical Sciences · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstrogen is known to decrease the risk of colon cancer in postmenopausal women, and may exert its actions by decreasing interleukin-6 (IL6) production via stabilization of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB). Estrogens are biosynthesized by CYP19A1 (aromatase), so it is possible that genetic variations in CYP19A1 influences the risk of colon cancer by altering expression of CYP19A1. Further, studies on gene-gene interactions suggest that single nucleotide polymorphisms in one gene may affect expression of other genes. The current study aims to explore the role of CYP19A1 single nucleotide polymorphisms on CYP19A1, NFκB1 and IL6 gene expression.

methodsPhenotype-genotype associations, cross-associations between genes, and haplotype analyses were performed in both normal human colon (n=82) and liver (n=238) samples.

resultsCYP19A1 rs10459592, rs1961177, and rs6493497 were associated with CYP19A1 expression in colon samples (P=0.042, P=0.041, and P=0.013, respectively). CYP19A1 single nucleotide polymorphisms (rs12908960, rs730154, rs8025191, and rs17523880) were correlated with NFκB1 expression (P=0.047, P=0.04, P=0.05, and P=0.03, respectively), and CYP19A1 rs11856927, rs2470152, and rs2470144 (P=0.049, P=0.025, P=0.047, respectively) were associated with IL6 expression in the colon. While rs730154 and rs17523880 could not be analyzed in the liver samples, none of the other associations with the colon were replicated in the liver samples. Haplotype analysis revealed three separate haplotypes of the CYP19A1 single nucleotide polymorphism that were significantly associated with CYP19A1, NFκB1, and IL6 gene expression.

conclusionCYP19A1 single nucleotide polymorphisms are associated not only with CYP19A1 expression but also with NFκB1 and IL6 expression. These data demonstrate the possible functional consequences of genetic variation within the CYP19A1 gene on other genes in a biologically plausible pathway.

Indexed as

colonCYP19A1interleukin-6liverNFκB1single nucleotide polymorphism

Identifiers

PMID25114581
PMCPMC4109316
OpenAlexW2095435457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.