ArticleMolecular & general genetics : MGG1989
Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine.
Article in Molecular & general genetics : MGG, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 44 citations in OpenAlex.
- Unusual Occurrence of Two Bona-Fide CCA-Adding Enzymes inInternational journal of molecular sciences · 2020Article
- Expression, identification and purification of Dictyostelium acetoacetyl-coa thiolase expressed in Escherichia coli.International journal of biological sciences · 2010Article
- Isolation and characterization of casein kinase I from Dictyostelium discoideum.The Biochemical journal · 2000Article
- Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium.The Journal of cell biology · 1999Article
- Simple sequence is abundant in eukaryotic proteins.Protein science : a publication of the Protein Society · 1999Article
- A developmentally regulated kinesin-related motor protein from Dictyostelium discoideum.Molecular biology of the cell · 1998Article
- Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.Molecular and cellular biology · 1996Article
- Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins.Molecular and cellular biology · 1996Article
- A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.Molecular and cellular biology · 1994Article
- PF1: an A-T hook-containing DNA binding protein from rice that interacts with a functionally defined d(AT)-rich element in the oat phytochrome A3 gene promoter.The Plant cell · 1994Article
- A novel AT-rich DNA binding protein that combines an HMG I-like DNA binding domain with a putative transcription domain.The Plant cell · 1994Article
- A repetitive DNA sequence in Paramecium macronuclei is related to the beta subunit of G proteins.Nucleic acids research · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A Dictyostelium discoideum repetitive element composed of long repeats of the codon (AAC) is found in developmentally regulated transcripts. The concentration of (AAC) sequences is low in mRNA from dormant spores and growing cells and increases markedly during spore germination and multicellular development. The sequence hybridizes to many different sized Dictyostelium DNA restriction fragments indicating that it is scattered throughout the genome. Four cDNA clones isolated contain (AAC) sequences in the deduced coding region. Interestingly, the (AAC)-rich sequences are present in all three reading frames in the deduced proteins, i.e., AAC (asparagine), ACA (threonine) and CAA (glutamine). Three of the clones contain only one of these in-frame so that the individual proteins carry either asparagine, threonine, or glutamine clusters, not mixtures. However, one clone is both glutamine- and asparagine-rich. The (AAC) portion of the transcripts are reiterated 300 times in the haploid genome while the other portions of the cDNAs represent single copy genes, whose sequences show no similarity other than the (AAC) repeats. The repeated sequence is similar to the opa or M sequence found in Drosophila melanogaster notch and homeo box genes and in fly developmentally regulated transcripts. The transcripts are present on polysomes suggesting that they are translated. Although the function of these repeats is unknown, long amino acid repeats are a characteristic feature of extracellular proteins of lower eukaryotes.
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