ArticleThe American journal of tropical medicine and hygiene2014
Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh.
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Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30citing papers in PubMed, 1 pooled it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Estimating the proportion of clinically suspected cholera cases that are true Vibrio cholerae infections: A systematic review and meta-analysis.PLoS medicine · 2023Pooled it
- Potential for Controlling Cholera Using a Ring Vaccination Strategy: Re-analysis of Data from a Cluster-Randomized Clinical Trial.PLoS medicine · 2016Trial
- Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases From Household Microbiological and Clinical Data.The Journal of infectious diseases · 2026Article
- Environmental surveillance of pathogens in Africa.Applied and environmental microbiology · 2026Review
- Quantifying the population-level impact of expanded antibiotic treatment for cholera outbreak management.PLoS computational biology · 2026Article
- Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases from Household Microbiological and Clinical Data.medRxiv : the preprint server for health sciences · 2026Article
- Congruity of genomic and epidemiological data in modelling of local cholera outbreaks.Proceedings. Biological sciences · 2024Article
- Water pollution, cholera, and the role of probiotics: a comprehensive review in relation to public health in Bangladesh.Frontiers in microbiology · 2024Review
- Acute Renal Failure Secondary toJournal of community hospital internal medicine perspectives · 2024Article
- Food as a Driver of a Cholera Epidemic in Jijiga, Ethiopia-June 2017.The American journal of tropical medicine and hygiene · 2023Article
- Implementation of targeted cholera response activities, Cameroon.Bulletin of the World Health Organization · 2023Article
- The Role of Nutrients and Nutritional Signals in the Pathogenesis of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Worker Protection Scenarios for General Analytical Testing Facility under Several Infection Propagation Risks: Scoping Review, Epidemiological Model and ISO 31000.International journal of environmental research and public health · 2022Article
- Article
- Article
- Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh.Frontiers in immunology · 2022Article
- Article
- Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera.mSphere · 2021Article
- Spatial clustering of cholera cases in the Kathmandu Valley: implications for a ring vaccination strategy.International health · 2021Article
- Risk Factors for Epidemic Cholera in Lusaka, Zambia-2017.The American journal of tropical medicine and hygiene · 2020Article
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Authors and funding
11 authors.
Ana A WeilDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Yasmin BegumDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Fahima ChowdhuryDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Ashraful I KhanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Daniel T LeungDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Regina C LaRocqueDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Richelle C CharlesDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Edward T RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Stephen B CalderwoodDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Firdausi QadriDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.
Jason B HarrisDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Department of Microbiology and Immunobiology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts jbharris@partners.org.
Funding
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6MINFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1MImmune Responses to Vibrio cholerae infection and vaccination in HaitiR01AI099243 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, JASON B, IVERS, LOUISE C. · 2012 to 2022
$7.9MProtecutive immunity to human cholera in BangladeshU01AI058935 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CALDERWOOD, STEPHEN B., RYAN, EDWARD T. · 2003 to 2014
$7.8MHigh throughput NAPPA-proteoimmunomics and Vibrio cholerae vaccine developmentU01AI077883 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2008 to 2012
$5.6MTraining program in vaccine development and public healthD43TW005572 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI QADRI, FIRDAUSI, RYAN, EDWARD T. · 2000 to 2025
$5.4MO-Specific Polysaccharide Responses and CholeraR37AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Edward T. Ryan · 2020 to 2026
$5.1MInnate and early B cell responses to V. choleraeR01AI103055 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, JASON B · 2014 to 2018
$3.9MO-Specific Polysaccharide Responses and CholeraR01AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2018
$3.7MO-Specific Polysaccharide Responses and CholeraR56AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2013 to 2020
$843kImmune Responses to Vibrio Cholerae in ChildrenK08AI100923 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2012 to 2016
$686kHigh-throughput proteomic study of protective immunity in human cholera infectionK08AI089721 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHARLES, RICHELLE C · 2010 to 2014
$684kFIC NIH HHS D43 TW005572FIC NIH HHS R24 TW007988FIC NIH HHS TW005572NIAID NIH HHS AI058935NIAID NIH HHS AI106878NIAID NIH HHS K08 AI089721NIAID NIH HHS K08 AI100923NIAID NIH HHS R01AI03055NIAID NIH HHS R01 AI099243NIAID NIH HHS R01 AI103055NIAID NIH HHS R01 AI106878NIAID NIH HHS R03 AI063079NIAID NIH HHS R37 AI106878NIAID NIH HHS R56 AI106878NIAID NIH HHS T32 AI007061NIAID NIH HHS U01 AI058935NIAID NIH HHS U01 AI077883
Abstract
Multiple Vibrio cholerae infections within the same household are common. Household contacts of patients with cholera were observed with daily clinical assessments and collection of rectal swab cultures for nine days after presentation of the index case. During the follow-up period, 71 (24%) of 294 household contacts developed a positive V. cholerae rectal swab, signifying bacterial shedding. The average length of bacterial shedding was 2.0 days (95% confidence interval 1.7-2.4). However, 16 (5%) of 294 contacts shed V. cholerae for ≥ 4 days. In a multivariate analysis, malnutrition was predictive of long-term shedding (odds ratio = 1.4, 95% confidence interval = 1.3-13, P = 0.02). High rates of V. cholerae infection and bacterial shedding among household contacts of cholera patients represent an opportunity for intervention to reduce V. cholerae transmission.
Indexed as
Bacterial SheddingAdolescentAdultAge DistributionBangladeshChildChild, PreschoolCholeraCohort StudiesDiarrheaFamily CharacteristicsFecesFemaleHumansMaleMalnutrition
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